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Systematic AI-assisted screening of the cadhesome to map epithelial monolayer mechanics.

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Title: Systematic AI-assisted screening of the cadhesome to map epithelial monolayer mechanics.
Authors: Bertocchi C; Faculty of Biological Sciences, Laboratory for Molecular Mechanics of Cell Adhesion, Pontificia Universidad Católica de Chile, Santiago, Chile. cbertocchi@uc.cl.; Graduate School of Engineering Science, The University of Osaka, Osaka, Japan. cbertocchi@uc.cl., Alegría JJ; Millennium Institute Foundational Research on Data, Santiago, Chile., Vásquez-Sepúlveda S; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; Medical Institute of Biophysics, Friedrich-Alexander-Universität Erlangen-Nürnberg and Max-Planck- Zentrum für Physik und Medizin, Erlangen, Germany., Ibanez-Prat R; Graduate School of Engineering Science, The University of Osaka, Osaka, Japan.; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Srinivasan A; Mechanobiology Institute, National University of Singapore, Singapore, Singapore., Arrano-Valenzuela I; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Castro-Pereira B; Faculty of Biological Sciences, Laboratory for Molecular Mechanics of Cell Adhesion, Pontificia Universidad Católica de Chile, Santiago, Chile., Soto-Montandon C; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Trujillo-Espergel A; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Montenegro-Rojas I; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Deguchi S; Graduate School of Engineering Science, The University of Osaka, Osaka, Japan., Owen GI; Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; Department of Hematology and Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Center for Cancer prevention and Control (FONDAP-CECAN), Santiago, Chile.; Advanced Center for Chronic Diseases (FONDAP-ACCDiS), Santiago, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago, Chile., Kanchanawong P; Mechanobiology Institute, National University of Singapore, Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore., Cerda M; Faculty of Medicine, Center for Medical Informatics and Telemedicine, Universidad de Chile, Santiago, Chile.; Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile.; Department of Computer Science, Faculty of Physical and Mathematical Sciences, Santiago, Chile., Motta G; Data Science Institute, Columbia University, New York, USA., Zaidel-Bar R; Gray School of Medical Sciences, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Ravasio A; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile. and.ravasio@gmail.com.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 Jul 03. Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
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  Data: Systematic AI-assisted screening of the cadhesome to map epithelial monolayer mechanics.
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  Data: <searchLink fieldCode="AU" term="%22Bertocchi+C%22">Bertocchi C</searchLink>; Faculty of Biological Sciences, Laboratory for Molecular Mechanics of Cell Adhesion, Pontificia Universidad Católica de Chile, Santiago, Chile. cbertocchi@uc.cl.; Graduate School of Engineering Science, The University of Osaka, Osaka, Japan. cbertocchi@uc.cl.<br /><searchLink fieldCode="AU" term="%22Alegría+JJ%22">Alegría JJ</searchLink>; Millennium Institute Foundational Research on Data, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Vásquez-Sepúlveda+S%22">Vásquez-Sepúlveda S</searchLink>; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; Medical Institute of Biophysics, Friedrich-Alexander-Universität Erlangen-Nürnberg and Max-Planck- Zentrum für Physik und Medizin, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Ibanez-Prat+R%22">Ibanez-Prat R</searchLink>; Graduate School of Engineering Science, The University of Osaka, Osaka, Japan.; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Srinivasan+A%22">Srinivasan A</searchLink>; Mechanobiology Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Arrano-Valenzuela+I%22">Arrano-Valenzuela I</searchLink>; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Castro-Pereira+B%22">Castro-Pereira B</searchLink>; Faculty of Biological Sciences, Laboratory for Molecular Mechanics of Cell Adhesion, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Soto-Montandon+C%22">Soto-Montandon C</searchLink>; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Trujillo-Espergel+A%22">Trujillo-Espergel A</searchLink>; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Montenegro-Rojas+I%22">Montenegro-Rojas I</searchLink>; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Deguchi+S%22">Deguchi S</searchLink>; Graduate School of Engineering Science, The University of Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Owen+GI%22">Owen GI</searchLink>; Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; Department of Hematology and Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Center for Cancer prevention and Control (FONDAP-CECAN), Santiago, Chile.; Advanced Center for Chronic Diseases (FONDAP-ACCDiS), Santiago, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Kanchanawong+P%22">Kanchanawong P</searchLink>; Mechanobiology Institute, National University of Singapore, Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Cerda+M%22">Cerda M</searchLink>; Faculty of Medicine, Center for Medical Informatics and Telemedicine, Universidad de Chile, Santiago, Chile.; Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile.; Department of Computer Science, Faculty of Physical and Mathematical Sciences, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Motta+G%22">Motta G</searchLink>; Data Science Institute, Columbia University, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zaidel-Bar+R%22">Zaidel-Bar R</searchLink>; Gray School of Medical Sciences, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Ravasio+A%22">Ravasio A</searchLink>; Lab for Mechanobiology of Transforming Systems, Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile. and.ravasio@gmail.com.
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