Pilot spatial transcriptomics of dental pulpitis suggests immune-fibroblast profiling linked to reversibility.

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Title: Pilot spatial transcriptomics of dental pulpitis suggests immune-fibroblast profiling linked to reversibility.
Authors: Zaky S; Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA. shz33@pitt.edu.; Center for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA. shz33@pitt.edu., Rajasundaram D; Department of Pediatrics, Division of Health Informatics, Children's Hospital of Pittsburgh, Pittsburgh, USA.; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, USA., Lee AL; Institute for Quantitative Biomedicine, Rutgers University, Piscataway, New Jersey, USA., Summersgill K; Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA., Levine S; Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA., Boulos O; Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA., Dunn S; Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA., Intini G; Center for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.; Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA., Sfeir C; Center for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.; Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA., Silva R; Department of Endodontics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA. renato.silva@pitt.edu.
Source: Journal of translational medicine [J Transl Med] 2026 Jul 03; Vol. 24 (1). Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zaky+S%22">Zaky S</searchLink>; Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA. shz33@pitt.edu.; Center for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA. shz33@pitt.edu.<br /><searchLink fieldCode="AU" term="%22Rajasundaram+D%22">Rajasundaram D</searchLink>; Department of Pediatrics, Division of Health Informatics, Children's Hospital of Pittsburgh, Pittsburgh, USA.; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Lee+AL%22">Lee AL</searchLink>; Institute for Quantitative Biomedicine, Rutgers University, Piscataway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Summersgill+K%22">Summersgill K</searchLink>; Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Levine+S%22">Levine S</searchLink>; Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Boulos+O%22">Boulos O</searchLink>; Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Dunn+S%22">Dunn S</searchLink>; Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Intini+G%22">Intini G</searchLink>; Center for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.; Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Sfeir+C%22">Sfeir C</searchLink>; Center for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.; Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Silva+R%22">Silva R</searchLink>; Department of Endodontics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA. renato.silva@pitt.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-08520-4
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        Text: English
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              Text: 2026 Jul 03
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