View in EDS

Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).

Saved in:
Bibliographic Details
Title: Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).
Authors: Palleis C; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany. carla.palleis@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. carla.palleis@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. carla.palleis@med.uni-muenchen.de.; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany, Marchioninistraße 15, 81377. carla.palleis@med.uni-muenchen.de., Weidinger E; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Maaß S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany., Linke M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Brendel M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Nuclear Medicine, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Stöcklein S; Department of Radiology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Al Tawil A; Institut Für Medizinische Informationsverarbeitung, Biometrie Und Epidemiologie (IBE), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Mansmann U; Institut Für Medizinische Informationsverarbeitung, Biometrie Und Epidemiologie (IBE), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Teupser D; Institute of Laboratory Medicine, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Borst T; Pharmacy of the University Hospital Erlangen, Uniklinikum Erlangen, Erlangen, Germany., Heimke-Brinck R; Pharmacy of the University Hospital Erlangen, Uniklinikum Erlangen, Erlangen, Germany., Hemmer B; Department of Neurology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany., Höglinger GU; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Bidner H; TUM School of Medicine and Health, Muenchner Studienzentrum (MSZ), Technical University Munich, Munich, Germany., Simons M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany.; Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Levin J; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany. johannes.levin@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. johannes.levin@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. johannes.levin@med.uni-muenchen.de.
Source: Neurological research and practice [Neurol Res Pract] 2026 Jul 03; Vol. 8 (1). Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: BMC Country of Publication: England NLM ID: 101767802 Publication Model: Electronic Cited Medium: Internet ISSN: 2524-3489 (Electronic) Linking ISSN: 25243489 NLM ISO Abbreviation: Neurol Res Pract Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42400090
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Palleis+C%22">Palleis C</searchLink>; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany. carla.palleis@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. carla.palleis@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. carla.palleis@med.uni-muenchen.de.; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany, Marchioninistraße 15, 81377. carla.palleis@med.uni-muenchen.de.<br /><searchLink fieldCode="AU" term="%22Weidinger+E%22">Weidinger E</searchLink>; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Maaß+S%22">Maaß S</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Linke+M%22">Linke M</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Brendel+M%22">Brendel M</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Nuclear Medicine, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Stöcklein+S%22">Stöcklein S</searchLink>; Department of Radiology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Al+Tawil+A%22">Al Tawil A</searchLink>; Institut Für Medizinische Informationsverarbeitung, Biometrie Und Epidemiologie (IBE), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mansmann+U%22">Mansmann U</searchLink>; Institut Für Medizinische Informationsverarbeitung, Biometrie Und Epidemiologie (IBE), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Teupser+D%22">Teupser D</searchLink>; Institute of Laboratory Medicine, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Borst+T%22">Borst T</searchLink>; Pharmacy of the University Hospital Erlangen, Uniklinikum Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Heimke-Brinck+R%22">Heimke-Brinck R</searchLink>; Pharmacy of the University Hospital Erlangen, Uniklinikum Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Hemmer+B%22">Hemmer B</searchLink>; Department of Neurology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Höglinger+GU%22">Höglinger GU</searchLink>; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bidner+H%22">Bidner H</searchLink>; TUM School of Medicine and Health, Muenchner Studienzentrum (MSZ), Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Simons+M%22">Simons M</searchLink>; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany.; Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Levin+J%22">Levin J</searchLink>; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany. johannes.levin@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. johannes.levin@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. johannes.levin@med.uni-muenchen.de.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101767802%22">Neurological research and practice</searchLink> [Neurol Res Pract] 2026 Jul 03; Vol. 8 (1). <i>Date of Electronic Publication: </i>2026 Jul 03.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMC%22">BMC </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101767802 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2524-3489 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225243489%22">25243489 </searchLink><i>NLM ISO Abbreviation: </i>Neurol Res Pract <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42400090
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1186/s42466-026-00504-5
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Palleis C
      – PersonEntity:
          Name:
            NameFull: Weidinger E
      – PersonEntity:
          Name:
            NameFull: Maaß S
      – PersonEntity:
          Name:
            NameFull: Linke M
      – PersonEntity:
          Name:
            NameFull: Brendel M
      – PersonEntity:
          Name:
            NameFull: Stöcklein S
      – PersonEntity:
          Name:
            NameFull: Al Tawil A
      – PersonEntity:
          Name:
            NameFull: Mansmann U
      – PersonEntity:
          Name:
            NameFull: Teupser D
      – PersonEntity:
          Name:
            NameFull: Borst T
      – PersonEntity:
          Name:
            NameFull: Heimke-Brinck R
      – PersonEntity:
          Name:
            NameFull: Hemmer B
      – PersonEntity:
          Name:
            NameFull: Höglinger GU
      – PersonEntity:
          Name:
            NameFull: Bidner H
      – PersonEntity:
          Name:
            NameFull: Simons M
      – PersonEntity:
          Name:
            NameFull: Levin J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 03
              M: 07
              Text: 2026 Jul 03
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2524-3489
          Numbering:
            – Type: volume
              Value: 8
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Neurological research and practice
              Type: main
ResultId 1