Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).
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| Title: | Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS). |
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| Authors: | Palleis C; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany. carla.palleis@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. carla.palleis@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. carla.palleis@med.uni-muenchen.de.; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany, Marchioninistraße 15, 81377. carla.palleis@med.uni-muenchen.de., Weidinger E; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Maaß S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany., Linke M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Brendel M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Nuclear Medicine, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Stöcklein S; Department of Radiology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Al Tawil A; Institut Für Medizinische Informationsverarbeitung, Biometrie Und Epidemiologie (IBE), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Mansmann U; Institut Für Medizinische Informationsverarbeitung, Biometrie Und Epidemiologie (IBE), LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Teupser D; Institute of Laboratory Medicine, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Borst T; Pharmacy of the University Hospital Erlangen, Uniklinikum Erlangen, Erlangen, Germany., Heimke-Brinck R; Pharmacy of the University Hospital Erlangen, Uniklinikum Erlangen, Erlangen, Germany., Hemmer B; Department of Neurology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany., Höglinger GU; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Bidner H; TUM School of Medicine and Health, Muenchner Studienzentrum (MSZ), Technical University Munich, Munich, Germany., Simons M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany.; Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany., Levin J; Department of Neurology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität München, Munich, Germany. johannes.levin@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. johannes.levin@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. johannes.levin@med.uni-muenchen.de. |
| Source: | Neurological research and practice [Neurol Res Pract] 2026 Jul 03; Vol. 8 (1). Date of Electronic Publication: 2026 Jul 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BMC Country of Publication: England NLM ID: 101767802 Publication Model: Electronic Cited Medium: Internet ISSN: 2524-3489 (Electronic) Linking ISSN: 25243489 NLM ISO Abbreviation: Neurol Res Pract Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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