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Alpha-Particle Therapy with an Actinium-225 Labeled Bivalent Inhibitor of Prostate-Specific Membrane Antigen is Therapeutically Efficacious in a Mouse Model of Prostate Cancer.

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Title: Alpha-Particle Therapy with an Actinium-225 Labeled Bivalent Inhibitor of Prostate-Specific Membrane Antigen is Therapeutically Efficacious in a Mouse Model of Prostate Cancer.
Authors: Morgan KA; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010 Victoria, Australia., Grieve ML; Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.; ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR), the University of Queensland, Brisbane, QLD 4072, Australia., Akhter DT; Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.; ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR), the University of Queensland, Brisbane, QLD 4072, Australia., Lange JL; Clarity Pharmaceuticals Ltd., National Innovation Centre, 4 Cornwallis Street, Eveleigh, New South Wales 2042, Australia., Harris MJ; Clarity Pharmaceuticals Ltd., National Innovation Centre, 4 Cornwallis Street, Eveleigh, New South Wales 2042, Australia., Thurecht KJ; Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.; ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR), the University of Queensland, Brisbane, QLD 4072, Australia., Paterson BM; Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.; ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR), the University of Queensland, Brisbane, QLD 4072, Australia., Donnelly PS; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010 Victoria, Australia.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jul 23; Vol. 69 (14), pp. 17462-17472. Date of Electronic Publication: 2026 Jul 04.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Alpha-Particle Therapy with an Actinium-225 Labeled Bivalent Inhibitor of Prostate-Specific Membrane Antigen is Therapeutically Efficacious in a Mouse Model of Prostate Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Morgan+KA%22">Morgan KA</searchLink>; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010 Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Grieve+ML%22">Grieve ML</searchLink>; Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.; ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR), the University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Akhter+DT%22">Akhter DT</searchLink>; Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.; ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR), the University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Lange+JL%22">Lange JL</searchLink>; Clarity Pharmaceuticals Ltd., National Innovation Centre, 4 Cornwallis Street, Eveleigh, New South Wales 2042, Australia.<br /><searchLink fieldCode="AU" term="%22Harris+MJ%22">Harris MJ</searchLink>; Clarity Pharmaceuticals Ltd., National Innovation Centre, 4 Cornwallis Street, Eveleigh, New South Wales 2042, Australia.<br /><searchLink fieldCode="AU" term="%22Thurecht+KJ%22">Thurecht KJ</searchLink>; Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.; ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR), the University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Paterson+BM%22">Paterson BM</searchLink>; Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.; ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR), the University of Queensland, Brisbane, QLD 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Donnelly+PS%22">Donnelly PS</searchLink>; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010 Victoria, Australia.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jul 23; Vol. 69 (14), pp. 17462-17472. <i>Date of Electronic Publication: </i>2026 Jul 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.6c01378
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        Text: English
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      – TitleFull: Alpha-Particle Therapy with an Actinium-225 Labeled Bivalent Inhibitor of Prostate-Specific Membrane Antigen is Therapeutically Efficacious in a Mouse Model of Prostate Cancer.
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              Text: 2026 Jul 23
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