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CAF-derived PAI-1 serves as an EGFR ligand and fuels KRAS-mutant pancreatic cancer.

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Title: CAF-derived PAI-1 serves as an EGFR ligand and fuels KRAS-mutant pancreatic cancer.
Authors: Wang Y; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin, China., Liu C; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin, China., Gao S; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Tianjin Key Laboratory of Digestive Cancer, Tianjin, China., Wang B; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Wang H; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Tianjin Key Laboratory of Digestive Cancer, Tianjin, China., Shi Z; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Xia S; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Li J; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Yao X; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin, China., Guo X; Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Tianjin Key Laboratory of Digestive Cancer, Tianjin, China., Zheng J; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Zhou Q; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Chen Z; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Zheng L; Department of Colorectal Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Zhang Q; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin, China., Du J; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Zhou T; Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Tianjin Key Laboratory of Digestive Cancer, Tianjin, China., Zhang Z; Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Tianjin Key Laboratory of Digestive Cancer, Tianjin, China., Song W; Laboratory Animal Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Qi L; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Wang Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Sher YP; Institute of Biochemistry and Molecular Biology, China Medical University, Taichung, Taiwan.; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan., Li M; Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma, USA. Min-Li@ouhsc.edu.; Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma, USA. Min-Li@ouhsc.edu., Zhou X; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. xuanzhou@tmu.edu.cn.; State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. xuanzhou@tmu.edu.cn.; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. xuanzhou@tmu.edu.cn.; Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin, China. xuanzhou@tmu.edu.cn., Hung MC; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan. mhung@cmu.edu.tw.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw., Ren Y; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. yuren0925@tmu.edu.cn.; State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. yuren0925@tmu.edu.cn.; Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin, China. yuren0925@tmu.edu.cn., Hao J; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. haojihui@tjmuch.com.; State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. haojihui@tjmuch.com.; Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. haojihui@tjmuch.com.; Tianjin Key Laboratory of Digestive Cancer, Tianjin, China. haojihui@tjmuch.com.
Source: Nature communications [Nat Commun] 2026 Jul 04. Date of Electronic Publication: 2026 Jul 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CAF-derived PAI-1 serves as an EGFR ligand and fuels KRAS-mutant pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.; 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Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Sher+YP%22">Sher YP</searchLink>; Institute of Biochemistry and Molecular Biology, China Medical University, Taichung, Taiwan.; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma, USA. Min-Li@ouhsc.edu.; Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma, USA. 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