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PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse.

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Title: PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse.
Authors: Mihuț A; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary.; Doctoral School of Multidisciplinary Medical Sciences, University of Szeged, H-6720, Szeged, Hungary., Ghosh D; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary.; Doctoral School of Biology, University of Szeged, H-6726, Szeged, Hungary., Kószó A; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary., Szüts D; Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, H-1117, Budapest, Hungary., Salajkova SA; Institute of Molecular Cancer Research, University of Zurich, Strickhofstrasse 40a, 8057, Zurich, Switzerland., Andrs M; Institute of Molecular Cancer Research, University of Zurich, Strickhofstrasse 40a, 8057, Zurich, Switzerland.; Department of Genome Biology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00, Prague 4, Czech Republic., Dobrovolna J; Department of Genome Biology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00, Prague 4, Czech Republic.; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 00, Prague 4, Czech Republic., Fajka-Boja R; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary. fajka_boja.roberta@brc.hu.; Department of Immunology, Albert Szent-Györgyi Medical School, Faculty of Science and Informatics, University of Szeged, H-6720, Szeged, Hungary. fajka_boja.roberta@brc.hu., Timinszky G; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary. timinszky.gyula@brc.hu.
Source: EMBO reports [EMBO Rep] 2026 Jul 04. Date of Electronic Publication: 2026 Jul 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mihuț+A%22">Mihuț A</searchLink>; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary.; Doctoral School of Multidisciplinary Medical Sciences, University of Szeged, H-6720, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Ghosh+D%22">Ghosh D</searchLink>; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary.; Doctoral School of Biology, University of Szeged, H-6726, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Kószó+A%22">Kószó A</searchLink>; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Szüts+D%22">Szüts D</searchLink>; Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, H-1117, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Salajkova+SA%22">Salajkova SA</searchLink>; Institute of Molecular Cancer Research, University of Zurich, Strickhofstrasse 40a, 8057, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Andrs+M%22">Andrs M</searchLink>; Institute of Molecular Cancer Research, University of Zurich, Strickhofstrasse 40a, 8057, Zurich, Switzerland.; Department of Genome Biology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00, Prague 4, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Dobrovolna+J%22">Dobrovolna J</searchLink>; Department of Genome Biology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00, Prague 4, Czech Republic.; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 00, Prague 4, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Fajka-Boja+R%22">Fajka-Boja R</searchLink>; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary. fajka_boja.roberta@brc.hu.; Department of Immunology, Albert Szent-Györgyi Medical School, Faculty of Science and Informatics, University of Szeged, H-6720, Szeged, Hungary. fajka_boja.roberta@brc.hu.<br /><searchLink fieldCode="AU" term="%22Timinszky+G%22">Timinszky G</searchLink>; Laboratory of DNA Damage and Nuclear Dynamics, Institute of Genetics, HUN-REN Biological Research Centre, H-6726, Szeged, Hungary. timinszky.gyula@brc.hu.
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