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Synergistic SGLT2 and GLP-1R targeting alleviates systemic inflammation-induced and M1 monocyte-driven endothelial dysfunction in coronary artery disease.

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Title: Synergistic SGLT2 and GLP-1R targeting alleviates systemic inflammation-induced and M1 monocyte-driven endothelial dysfunction in coronary artery disease.
Authors: Mroueh A; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France., Fakih W; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France., Kerth S; Experimental and Molecular Pediatric Cardiology, TUM University Hospital, German Heart Center Munich, Technical University Munich, Munich, Germany., Kikuchi S; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.; Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France., Aboueddahab C; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France., Gong DS; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.; College of Pharmacy, Mokpo National University, 1666 Yeongsan-Ro, Cheonggye-Myeon, Muan-Gun, Jeonnam, 58554, Republic of Korea., Choi M; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.; College of Pharmacy, Mokpo National University, 1666 Yeongsan-Ro, Cheonggye-Myeon, Muan-Gun, Jeonnam, 58554, Republic of Korea., Nicolas A; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France., Fass S; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France., Trimaille A; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France., Granier A; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France., Carmona A; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France., Amissi S; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France., Pompach P; Institute of Biotechnology, Czech Academy of Sciences, Vestec, Czech Republic., Oak MH; College of Pharmacy, Mokpo National University, 1666 Yeongsan-Ro, Cheonggye-Myeon, Muan-Gun, Jeonnam, 58554, Republic of Korea., Jesel L; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France., Görlach A; Experimental and Molecular Pediatric Cardiology, TUM University Hospital, German Heart Center Munich, Technical University Munich, Munich, Germany., Morel O; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France. olivier.morel@chru-strasbourg.fr.; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France. olivier.morel@chru-strasbourg.fr., Schini-Kerth V; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France. valerie.schini-kerth@unistra.fr.
Source: Cardiovascular diabetology [Cardiovasc Diabetol] 2026 Jul 04. Date of Electronic Publication: 2026 Jul 04.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synergistic SGLT2 and GLP-1R targeting alleviates systemic inflammation-induced and M1 monocyte-driven endothelial dysfunction in coronary artery disease.
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  Data: <searchLink fieldCode="AU" term="%22Mroueh+A%22">Mroueh A</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Fakih+W%22">Fakih W</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Kerth+S%22">Kerth S</searchLink>; Experimental and Molecular Pediatric Cardiology, TUM University Hospital, German Heart Center Munich, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kikuchi+S%22">Kikuchi S</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.; Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Aboueddahab+C%22">Aboueddahab C</searchLink>; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Gong+DS%22">Gong DS</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.; College of Pharmacy, Mokpo National University, 1666 Yeongsan-Ro, Cheonggye-Myeon, Muan-Gun, Jeonnam, 58554, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+M%22">Choi M</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.; College of Pharmacy, Mokpo National University, 1666 Yeongsan-Ro, Cheonggye-Myeon, Muan-Gun, Jeonnam, 58554, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Nicolas+A%22">Nicolas A</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Fass+S%22">Fass S</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Trimaille+A%22">Trimaille A</searchLink>; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Granier+A%22">Granier A</searchLink>; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Carmona+A%22">Carmona A</searchLink>; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Amissi+S%22">Amissi S</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Pompach+P%22">Pompach P</searchLink>; Institute of Biotechnology, Czech Academy of Sciences, Vestec, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Oak+MH%22">Oak MH</searchLink>; College of Pharmacy, Mokpo National University, 1666 Yeongsan-Ro, Cheonggye-Myeon, Muan-Gun, Jeonnam, 58554, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jesel+L%22">Jesel L</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France.; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Görlach+A%22">Görlach A</searchLink>; Experimental and Molecular Pediatric Cardiology, TUM University Hospital, German Heart Center Munich, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Morel+O%22">Morel O</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France. olivier.morel@chru-strasbourg.fr.; Cardiology Department, Strasbourg University Hospital, 1 Place de L'Hôpital, 67000, Strasbourg, France. olivier.morel@chru-strasbourg.fr.<br /><searchLink fieldCode="AU" term="%22Schini-Kerth+V%22">Schini-Kerth V</searchLink>; FMTS, Biomedicine Research Center of Strasbourg, UR 3074, Translational Cardiovascular Medicine, University of Strasbourg, 1 Rue Eugène Boeckel, 67000, Strasbourg, France. valerie.schini-kerth@unistra.fr.
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  Data: <searchLink fieldCode="JN" term="%22101147637%22">Cardiovascular diabetology</searchLink> [Cardiovasc Diabetol] 2026 Jul 04. <i>Date of Electronic Publication: </i>2026 Jul 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101147637 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-2840 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214752840%22">14752840 </searchLink><i>NLM ISO Abbreviation: </i>Cardiovasc Diabetol <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul 04
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