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Genomic dissection of hoof and leg conformation in Swiss dairy cattle populations reveals polygenic architecture and a recessive HYAL1 nonsense variant affecting longevity in Holstein cattle.

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Title: Genomic dissection of hoof and leg conformation in Swiss dairy cattle populations reveals polygenic architecture and a recessive HYAL1 nonsense variant affecting longevity in Holstein cattle.
Authors: Vasiljevic S; Institute of Genetics, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland., Seefried FR; Qualitas AG, 6300, Zug, Switzerland., Widmer S; Qualitas AG, 6300, Zug, Switzerland., Kadri NK; Institute of Agricultural Sciences, Animal Genomics, ETH Zürich, 8092, Zurich, Switzerland., Leonard AS; Institute of Agricultural Sciences, Animal Genomics, ETH Zürich, 8092, Zurich, Switzerland., He Q; Institute of Agricultural Sciences, Animal Genomics, ETH Zürich, 8092, Zurich, Switzerland., Pausch H; Institute of Agricultural Sciences, Animal Genomics, ETH Zürich, 8092, Zurich, Switzerland., Besnard F; Université Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France., Capitan A; Université Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France., Drögemüller C; Institute of Genetics, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland., Jacinto J; Institute of Genetics, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland. joana.jacinto@unibe.ch.; Clinic for Ruminants, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland. joana.jacinto@unibe.ch.
Source: Genetics, selection, evolution : GSE [Genet Sel Evol] 2026 Jul 05. Date of Electronic Publication: 2026 Jul 05.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: France NLM ID: 9114088 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1297-9686 (Electronic) Linking ISSN: 0999193X NLM ISO Abbreviation: Genet Sel Evol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genomic dissection of hoof and leg conformation in Swiss dairy cattle populations reveals polygenic architecture and a recessive HYAL1 nonsense variant affecting longevity in Holstein cattle.
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  Data: <searchLink fieldCode="AU" term="%22Vasiljevic+S%22">Vasiljevic S</searchLink>; Institute of Genetics, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Seefried+FR%22">Seefried FR</searchLink>; Qualitas AG, 6300, Zug, Switzerland.<br /><searchLink fieldCode="AU" term="%22Widmer+S%22">Widmer S</searchLink>; Qualitas AG, 6300, Zug, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kadri+NK%22">Kadri NK</searchLink>; Institute of Agricultural Sciences, Animal Genomics, ETH Zürich, 8092, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Leonard+AS%22">Leonard AS</searchLink>; Institute of Agricultural Sciences, Animal Genomics, ETH Zürich, 8092, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22He+Q%22">He Q</searchLink>; Institute of Agricultural Sciences, Animal Genomics, ETH Zürich, 8092, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pausch+H%22">Pausch H</searchLink>; Institute of Agricultural Sciences, Animal Genomics, ETH Zürich, 8092, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Besnard+F%22">Besnard F</searchLink>; Université Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.<br /><searchLink fieldCode="AU" term="%22Capitan+A%22">Capitan A</searchLink>; Université Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.<br /><searchLink fieldCode="AU" term="%22Drögemüller+C%22">Drögemüller C</searchLink>; Institute of Genetics, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jacinto+J%22">Jacinto J</searchLink>; Institute of Genetics, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland. joana.jacinto@unibe.ch.; Clinic for Ruminants, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland. joana.jacinto@unibe.ch.
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  Data: <searchLink fieldCode="JN" term="%229114088%22">Genetics, selection, evolution : GSE</searchLink> [Genet Sel Evol] 2026 Jul 05. <i>Date of Electronic Publication: </i>2026 Jul 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>9114088 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1297-9686 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220999193X%22">0999193X </searchLink><i>NLM ISO Abbreviation: </i>Genet Sel Evol <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12711-026-01068-3
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      – Code: eng
        Text: English
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      – TitleFull: Genomic dissection of hoof and leg conformation in Swiss dairy cattle populations reveals polygenic architecture and a recessive HYAL1 nonsense variant affecting longevity in Holstein cattle.
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            – D: 05
              M: 07
              Text: 2026 Jul 05
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              Y: 2026
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