A platelet-monocyte pyroptotic axis mediates uremic cardiomyopathy: critical role of PF4 and hematopoietic caspase-1.

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Title: A platelet-monocyte pyroptotic axis mediates uremic cardiomyopathy: critical role of PF4 and hematopoietic caspase-1.
Authors: Yang Y; Department of Nephrology, The 981st Hospital of Chinese People's Liberation Army, No. 3 Pu Ning Road, Shuangqiao District, Chengde, China. yybjzy@163.com., Zhang M; Department of Ultrasound, The Seventh Medical Center of PLA General Hospital, No. 5 Nanmencang, Dongcheng District, Beijing, China., Chen M; Center for Nephrology and Clinical Metabolomics, Division of Nephology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Jing'an District, Shanghai, China., Li X; Department of Ultrasound, Beidaihe Rehabilitation and Recuperation Center of the Chinese People's Liberation Army, No. 4 Xihaitan Road, Beidaihe District, Qinhuangdao, China., Xu J; Kidney Institution of the Chinese People's Liberation Army, Chang Zheng Hospital, The Navy Military Medical University, No. 415 Feng Yang Road, Huangpu District, Shanghai, China., Zhang T; National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, No. 305 Zhongshan East Road, Nanjing, China., Zhang D; Department of Nephrology, The 981st Hospital of Chinese People's Liberation Army, No. 3 Pu Ning Road, Shuangqiao District, Chengde, China., Kong D; Department of Nephrology, Shenzhen Bao'An District Song Gang Peopleohh Hospital, No. 2 Shajiang Road, Songgang Street, Bao'an District, Shenzhen, China., Ma L; Department of Nephrology, Beidaihe Rehabilitation and Recuperation Center of the Chinese People's Liberation Army, No. 4 Xihaitan Road, Beidaihe District, Qinhuangdao, China., Peng A; Center for Nephrology and Clinical Metabolomics, Division of Nephology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Jing'an District, Shanghai, China. pengai@tongji.edu.cn., Mei C; Kidney Institution of the Chinese People's Liberation Army, Chang Zheng Hospital, The Navy Military Medical University, No. 415 Feng Yang Road, Huangpu District, Shanghai, China. chlmei1954@126.com.
Source: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2026 Jul 06; Vol. 75 (1). Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article
Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9508160 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-908X (Electronic) Linking ISSN: 10233830 NLM ISO Abbreviation: Inflamm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A platelet-monocyte pyroptotic axis mediates uremic cardiomyopathy: critical role of PF4 and hematopoietic caspase-1.
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  Data: <searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Nephrology, The 981st Hospital of Chinese People's Liberation Army, No. 3 Pu Ning Road, Shuangqiao District, Chengde, China. yybjzy@163.com.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Ultrasound, The Seventh Medical Center of PLA General Hospital, No. 5 Nanmencang, Dongcheng District, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Center for Nephrology and Clinical Metabolomics, Division of Nephology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Jing'an District, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Ultrasound, Beidaihe Rehabilitation and Recuperation Center of the Chinese People's Liberation Army, No. 4 Xihaitan Road, Beidaihe District, Qinhuangdao, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Kidney Institution of the Chinese People's Liberation Army, Chang Zheng Hospital, The Navy Military Medical University, No. 415 Feng Yang Road, Huangpu District, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, No. 305 Zhongshan East Road, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Department of Nephrology, The 981st Hospital of Chinese People's Liberation Army, No. 3 Pu Ning Road, Shuangqiao District, Chengde, China.<br /><searchLink fieldCode="AU" term="%22Kong+D%22">Kong D</searchLink>; Department of Nephrology, Shenzhen Bao'An District Song Gang Peopleohh Hospital, No. 2 Shajiang Road, Songgang Street, Bao'an District, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Department of Nephrology, Beidaihe Rehabilitation and Recuperation Center of the Chinese People's Liberation Army, No. 4 Xihaitan Road, Beidaihe District, Qinhuangdao, China.<br /><searchLink fieldCode="AU" term="%22Peng+A%22">Peng A</searchLink>; Center for Nephrology and Clinical Metabolomics, Division of Nephology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Jing'an District, Shanghai, China. pengai@tongji.edu.cn.<br /><searchLink fieldCode="AU" term="%22Mei+C%22">Mei C</searchLink>; Kidney Institution of the Chinese People's Liberation Army, Chang Zheng Hospital, The Navy Military Medical University, No. 415 Feng Yang Road, Huangpu District, Shanghai, China. chlmei1954@126.com.
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  Data: <searchLink fieldCode="JN" term="%229508160%22">Inflammation research : official journal of the European Histamine Research Society ... [et al.]</searchLink> [Inflamm Res] 2026 Jul 06; Vol. 75 (1). <i>Date of Electronic Publication: </i>2026 Jul 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Birkhäuser%22">Birkhäuser </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9508160 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-908X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210233830%22">10233830 </searchLink><i>NLM ISO Abbreviation: </i>Inflamm Res <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00011-026-02311-9
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              Text: 2026 Jul 06
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              Y: 2026
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