REJENERA©, a multi-component bioflavonoid-based formula, alleviates osteoarthritis and provides chondroprotection by regulating the NLRP3-TXNIP-iNOS axis and inflammation: a comparative study with olive leaf nutraceuticals and ibuprofen.

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Title: REJENERA©, a multi-component bioflavonoid-based formula, alleviates osteoarthritis and provides chondroprotection by regulating the NLRP3-TXNIP-iNOS axis and inflammation: a comparative study with olive leaf nutraceuticals and ibuprofen.
Authors: Tepedelenlioglu HE; Department of Orthopedics and Traumatology, Ankara Dışkapı Training and Research Hospital, Ankara, Turkey.; Department of Medical Pharmacology, Cellular Stress Response and Signal Transduction Research Laboratory, Faculty of Medicine, Gazi University, Ankara, Turkey., Elmazoglu Z; Department of Pharmacology, Faculty of Pharmacy, Ankara Medipol University, Ankara, Turkey., Saribas SG; Department of Histology and Embryology, Faculty of Medicine, Health Sciences University Gulhane, Ankara, Turkey., Tutuncu Y; Department of Immunology, School of Medicine, Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, Turkey.; Department of Medical Microbiology, Inonu University Faculty of Medicine, Malatya, Turkey., Ceylan AF; Department of Medical Pharmacology, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey., Karasu Ç; Department of Medical Pharmacology, Cellular Stress Response and Signal Transduction Research Laboratory, Faculty of Medicine, Gazi University, Ankara, Turkey. karasu@gazi.edu.tr.
Source: Inflammopharmacology [Inflammopharmacology] 2026 Jul 06. Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article
Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1568-5608
DOI:10.1007/s10787-026-02314-2