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Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.

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Title: Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.
Authors: Tran TM; Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, United States of America., Hu Z; Office of Biostatistics Research, National Institutes of Health, Bethesda, United States of America., Kayentao K; Malaria Research and Training Centre, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Ongoiba A; Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Jones S; MMV Medicines for Malaria Venture, Geneva, Switzerland., Abla N; MMV Medicines for Malaria Venture, Geneva, Switzerland., Healy SA; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America., Cisse H; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America., Chang BH; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America., Skinner J; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America., Serebryannyy L; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Narpala SR; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Schlesinger R; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Low KH; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Kazmierski R; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Lin BC; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Dias J; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Doumbo S; 4Malaria Research and Training Centre, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Doumtabe D; 4Malaria Research and Training Centre, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Preston AC; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America., Li S; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America., Peterson ME; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America., Oberai A; Antigen Discovery, Irvine, United States of America., Shandling AD; Antigen Discovery, Irvine, United States of America., Campo JJ; Antigen Discovery, Irvine, United States of America., Murphy SC; Department of Laboratory Medicine and Pathology and Center for Emerging and, University of Washington, Seattle, United States of America., Telscher S; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Coates EE; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Capparelli EV; Departments of Pediatrics and Pharmacy, UC San Diego Schools of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, United States of America., Dolo A; Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Traore B; Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Seder RA; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America., Crompton PD; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Jul 02. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
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  Data: Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.
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  Data: <searchLink fieldCode="AU" term="%22Tran+TM%22">Tran TM</searchLink>; Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, United States of America.<br /><searchLink fieldCode="AU" term="%22Hu+Z%22">Hu Z</searchLink>; Office of Biostatistics Research, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Kayentao+K%22">Kayentao K</searchLink>; Malaria Research and Training Centre, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.<br /><searchLink fieldCode="AU" term="%22Ongoiba+A%22">Ongoiba A</searchLink>; Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.<br /><searchLink fieldCode="AU" term="%22Jones+S%22">Jones S</searchLink>; MMV Medicines for Malaria Venture, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Abla+N%22">Abla N</searchLink>; MMV Medicines for Malaria Venture, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Healy+SA%22">Healy SA</searchLink>; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Cisse+H%22">Cisse H</searchLink>; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Chang+BH%22">Chang BH</searchLink>; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Skinner+J%22">Skinner J</searchLink>; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Serebryannyy+L%22">Serebryannyy L</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Narpala+SR%22">Narpala SR</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Schlesinger+R%22">Schlesinger R</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Low+KH%22">Low KH</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Kazmierski+R%22">Kazmierski R</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Lin+BC%22">Lin BC</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Dias+J%22">Dias J</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Doumbo+S%22">Doumbo S</searchLink>; 4Malaria Research and Training Centre, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.<br /><searchLink fieldCode="AU" term="%22Doumtabe+D%22">Doumtabe D</searchLink>; 4Malaria Research and Training Centre, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.<br /><searchLink fieldCode="AU" term="%22Preston+AC%22">Preston AC</searchLink>; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Peterson+ME%22">Peterson ME</searchLink>; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Oberai+A%22">Oberai A</searchLink>; Antigen Discovery, Irvine, United States of America.<br /><searchLink fieldCode="AU" term="%22Shandling+AD%22">Shandling AD</searchLink>; Antigen Discovery, Irvine, United States of America.<br /><searchLink fieldCode="AU" term="%22Campo+JJ%22">Campo JJ</searchLink>; Antigen Discovery, Irvine, United States of America.<br /><searchLink fieldCode="AU" term="%22Murphy+SC%22">Murphy SC</searchLink>; Department of Laboratory Medicine and Pathology and Center for Emerging and, University of Washington, Seattle, United States of America.<br /><searchLink fieldCode="AU" term="%22Telscher+S%22">Telscher S</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Coates+EE%22">Coates EE</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Capparelli+EV%22">Capparelli EV</searchLink>; Departments of Pediatrics and Pharmacy, UC San Diego Schools of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, United States of America.<br /><searchLink fieldCode="AU" term="%22Dolo+A%22">Dolo A</searchLink>; Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.<br /><searchLink fieldCode="AU" term="%22Traore+B%22">Traore B</searchLink>; Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.<br /><searchLink fieldCode="AU" term="%22Seder+RA%22">Seder RA</searchLink>; Vaccine Research Center, National Institutes of Health, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Crompton+PD%22">Crompton PD</searchLink>; Division of Intramural Research, National Institutes of Health, Bethesda, United States of America.
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