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Phase I/Ib study evaluating safety, efficacy, pharmacokinetics and pharmacodynamics of NIZ985 monotherapy and in combination with an anti-PD-1 agent in patients with advanced solid tumors or lymphoma.

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Title: Phase I/Ib study evaluating safety, efficacy, pharmacokinetics and pharmacodynamics of NIZ985 monotherapy and in combination with an anti-PD-1 agent in patients with advanced solid tumors or lymphoma.
Authors: Garralda E; Vall d'Hebron University Hospital (VHIO), Barcelona, Spain. Electronic address: egarralda@vhio.net., Schöffski P; University Hospitals Leuven, Department of General Medical Oncology, Leuven Cancer Institute KU Leuven, Leuven, Belgium., Oberoi A; Vall d'Hebron University Hospital (VHIO), Barcelona, Spain., Schuler M; West German Cancer Center, University Hospital Essen, Essen, Germany., Richly H; West German Cancer Center, University Hospital Essen, Essen, Germany., Ascierto PA; Istituto Nazionale Tumori IRCCS Fondazione 'G. Pascale', Napoli, Italy; Università degli Studi di Napoli 'Federico II', Napoli, Italy., Lin CC; National Taiwan University Hospital, Taipei, Taiwan., Álvarez R; Medical Oncology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Patel SP; UC San Diego Moores Cancer Center, La Jolla, CA, USA., Xing Y; City of Hope Comprehensive Center, Duarte, CA, USA., Subbiah V; University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lewis N; Novartis Pharmaceuticals, USA., Patel S; Novartis Biomedical Research, USA., Wang-L-Akshman L; Novartis Biomedical Research, USA., Lee JB; Novartis Biomedical Research, USA., Hassounah NB; Novartis Biomedical Research, USA., Lee LH; Novartis Biomedical Research, USA., Roy M; Novartis Pharmaceuticals, USA., Banerjee S; Novartis Biomedical Research, USA., Reynolds A; Novartis Biomedical Research, USA., Koyama T; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan., Shimizu T; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Jun 24; Vol. 244, pp. 116899. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase I/Ib study evaluating safety, efficacy, pharmacokinetics and pharmacodynamics of NIZ985 monotherapy and in combination with an anti-PD-1 agent in patients with advanced solid tumors or lymphoma.
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  Data: <searchLink fieldCode="AU" term="%22Garralda+E%22">Garralda E</searchLink>; Vall d'Hebron University Hospital (VHIO), Barcelona, Spain. Electronic address: egarralda@vhio.net.<br /><searchLink fieldCode="AU" term="%22Schöffski+P%22">Schöffski P</searchLink>; University Hospitals Leuven, Department of General Medical Oncology, Leuven Cancer Institute KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Oberoi+A%22">Oberoi A</searchLink>; Vall d'Hebron University Hospital (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Schuler+M%22">Schuler M</searchLink>; West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Richly+H%22">Richly H</searchLink>; West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Ascierto+PA%22">Ascierto PA</searchLink>; Istituto Nazionale Tumori IRCCS Fondazione 'G. Pascale', Napoli, Italy; Università degli Studi di Napoli 'Federico II', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Lin+CC%22">Lin CC</searchLink>; National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Álvarez+R%22">Álvarez R</searchLink>; Medical Oncology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Patel+SP%22">Patel SP</searchLink>; UC San Diego Moores Cancer Center, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xing+Y%22">Xing Y</searchLink>; City of Hope Comprehensive Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Subbiah+V%22">Subbiah V</searchLink>; University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+N%22">Lewis N</searchLink>; Novartis Pharmaceuticals, USA.<br /><searchLink fieldCode="AU" term="%22Patel+S%22">Patel S</searchLink>; Novartis Biomedical Research, USA.<br /><searchLink fieldCode="AU" term="%22Wang-L-Akshman+L%22">Wang-L-Akshman L</searchLink>; Novartis Biomedical Research, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JB%22">Lee JB</searchLink>; Novartis Biomedical Research, USA.<br /><searchLink fieldCode="AU" term="%22Hassounah+NB%22">Hassounah NB</searchLink>; Novartis Biomedical Research, USA.<br /><searchLink fieldCode="AU" term="%22Lee+LH%22">Lee LH</searchLink>; Novartis Biomedical Research, USA.<br /><searchLink fieldCode="AU" term="%22Roy+M%22">Roy M</searchLink>; Novartis Pharmaceuticals, USA.<br /><searchLink fieldCode="AU" term="%22Banerjee+S%22">Banerjee S</searchLink>; Novartis Biomedical Research, USA.<br /><searchLink fieldCode="AU" term="%22Reynolds+A%22">Reynolds A</searchLink>; Novartis Biomedical Research, USA.<br /><searchLink fieldCode="AU" term="%22Koyama+T%22">Koyama T</searchLink>; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+T%22">Shimizu T</searchLink>; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Jun 24; Vol. 244, pp. 116899. <i>Date of Electronic Publication: </i>2026 Jun 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 24
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