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Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.

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Title: Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.
Authors: Walker SM; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada., Loutan AJ; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada., Tchesnokov EP; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada., Kocincova D; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada., Gordon CJ; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada., Escobedo RA; Texas Biomedical Research Institute, San Antonio, TX, USA., Jackson N; Texas Biomedical Research Institute, San Antonio, TX, USA., Vogel OA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Morsheimer K; Department of Virology, Microbiology and Immunology, Boston University, Boston, MA, USA., Park S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Gharpure A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Urbano I; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Heacock M; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Chen Z; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Pathak K; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Wolff KC; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Huerta L; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Bakowski MA; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Riva L; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Gupta AK; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Yu C; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Das K; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada; Molecular Structural and Translational Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium., Martinez-Sobrido L; Texas Biomedical Research Institute, San Antonio, TX, USA., Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Davey R; Department of Virology, Microbiology and Immunology, Boston University, Boston, MA, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Chanda S; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Chatterjee AK; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Götte M; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada. Electronic address: gotte@ualberta.ca.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Jul 06, pp. 113316. Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
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  Data: Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.
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  Data: <searchLink fieldCode="AU" term="%22Walker+SM%22">Walker SM</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Loutan+AJ%22">Loutan AJ</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Tchesnokov+EP%22">Tchesnokov EP</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Kocincova+D%22">Kocincova D</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Gordon+CJ%22">Gordon CJ</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Escobedo+RA%22">Escobedo RA</searchLink>; Texas Biomedical Research Institute, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+N%22">Jackson N</searchLink>; Texas Biomedical Research Institute, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vogel+OA%22">Vogel OA</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Morsheimer+K%22">Morsheimer K</searchLink>; Department of Virology, Microbiology and Immunology, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gharpure+A%22">Gharpure A</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Urbano+I%22">Urbano I</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Heacock+M%22">Heacock M</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pathak+K%22">Pathak K</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wolff+KC%22">Wolff KC</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Huerta+L%22">Huerta L</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bakowski+MA%22">Bakowski MA</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Riva+L%22">Riva L</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+AK%22">Gupta AK</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Das+K%22">Das K</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada; Molecular Structural and Translational Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Martinez-Sobrido+L%22">Martinez-Sobrido L</searchLink>; Texas Biomedical Research Institute, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Basler+CF%22">Basler CF</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Davey+R%22">Davey R</searchLink>; Department of Virology, Microbiology and Immunology, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+IA%22">Wilson IA</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chanda+S%22">Chanda S</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chatterjee+AK%22">Chatterjee AK</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Götte+M%22">Götte M</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada. Electronic address: gotte@ualberta.ca.
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