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MDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder.

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Title: MDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder.
Authors: Morley KC; Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia kirsten.morley@sydney.edu.au.; Edith Collins Centre for Translational Research, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, New South Wales, Australia., Arunogiri S; Eastern Health, Turning Point, Melbourne, Victoria, Australia.; Monash Addiction Research Centre, Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Mills K; The Matilda Centre for Research in Mental Health and Substance Use, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Watt J; Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Edith Collins Centre for Translational Research, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, New South Wales, Australia., Teesson M; The Matilda Centre for Research in Mental Health and Substance Use, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Baillie A; School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Lee YY; Health Economics Group, School of Public Health and Preventative Medicine, Monash University, Melbourne, Victoria, Australia.; School of Public Health, The University of Queensland, Brisbane, Queensland, Australia.; Queensland Centre for Mental Health Research, Brisbane, Queensland, Australia., Morse A; National Centre for Mental Health Research, Australian National University, Canberra, Australian Capital Territory, Australia., Back SE; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA., Lubman DI; Eastern Health, Turning Point, Melbourne, Victoria, Australia.; Monash Addiction Research Centre, Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Haber PS; Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Edith Collins Centre for Translational Research, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, New South Wales, Australia.
Source: BMJ open [BMJ Open] 2026 Jul 06; Vol. 16 (7), pp. e114896. Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: MDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder.
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  Data: <searchLink fieldCode="AU" term="%22Morley+KC%22">Morley KC</searchLink>; Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia kirsten.morley@sydney.edu.au.; Edith Collins Centre for Translational Research, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Arunogiri+S%22">Arunogiri S</searchLink>; Eastern Health, Turning Point, Melbourne, Victoria, Australia.; Monash Addiction Research Centre, Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Mills+K%22">Mills K</searchLink>; The Matilda Centre for Research in Mental Health and Substance Use, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Watt+J%22">Watt J</searchLink>; Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Edith Collins Centre for Translational Research, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Teesson+M%22">Teesson M</searchLink>; The Matilda Centre for Research in Mental Health and Substance Use, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Baillie+A%22">Baillie A</searchLink>; School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+YY%22">Lee YY</searchLink>; Health Economics Group, School of Public Health and Preventative Medicine, Monash University, Melbourne, Victoria, Australia.; School of Public Health, The University of Queensland, Brisbane, Queensland, Australia.; Queensland Centre for Mental Health Research, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Morse+A%22">Morse A</searchLink>; National Centre for Mental Health Research, Australian National University, Canberra, Australian Capital Territory, Australia.<br /><searchLink fieldCode="AU" term="%22Back+SE%22">Back SE</searchLink>; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Lubman+DI%22">Lubman DI</searchLink>; Eastern Health, Turning Point, Melbourne, Victoria, Australia.; Monash Addiction Research Centre, Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Haber+PS%22">Haber PS</searchLink>; Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Edith Collins Centre for Translational Research, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, New South Wales, Australia.
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2026 Jul 06; Vol. 16 (7), pp. e114896. <i>Date of Electronic Publication: </i>2026 Jul 06.
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              Text: 2026 Jul 06
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