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Fibronectin-induced overactivation of αVβ3-PI3K-PIP3-PDK1-ILK signaling drives aortic disease in Marfan syndrome.

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Title: Fibronectin-induced overactivation of αVβ3-PI3K-PIP3-PDK1-ILK signaling drives aortic disease in Marfan syndrome.
Authors: Alarcón-Ruiz I; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Ruiz-Rodríguez MJ; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Surgery (Cardiac), Yale School of Medicine, New Haven, CT, USA., Martínez-Martínez S; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Toral M; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain., Martín-Bermejo N; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Mateos-García S; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Gil-Ruiz T; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain., Herrero-Galán E; Molecular Mechanics of the Cardiovascular System, CNIC, Madrid, Spain., Méndez-Olivares MJ; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., López-Maderuelo D; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Microscopy and Dynamic Imaging Unit, CNIC, Madrid, Spain., Gutiérrez-Martínez C; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain., Clemente C; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain., Clemente-Manteca A; Molecular Mechanics of the Cardiovascular System, CNIC, Madrid, Spain., H-Alcántara A; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain., Guala A; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Cardiology, Hospital Universitari Vall d'Hebron & Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain., Evangelista A; Teknon Medical Centre-Quironsalud, Heart Institute, Barcelona, Spain., Teixido-Tura G; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Cardiology, Hospital Universitari Vall d'Hebron & Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain., Rodríguez-Puyol D; Department of Medicine, Universidad de Alcalá de Henares & Nephrology Department, Hospital Príncipe de Asturias, Alcalá de Henares; Instituto Ramon y Cajal de Investigación Sanitaria (IRYCIS), Fundación Renal Iñigo Álvarez de Toledo (FRIAT) & RICOR from Instituto de Salud Carlos III and NOVELREN from Comunidad de Madrid, Madrid, Spain., Nistal JF; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Cardiovascular Surgery, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, Santander, Spain., Alegre-Cebollada J; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Molecular Mechanics of the Cardiovascular System, CNIC, Madrid, Spain., Vázquez J; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Cardiovascular Proteomics, CNIC, Madrid, Spain., Duarte J; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain., Redondo JM; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. jmredondo@cbm.csic.es.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. jmredondo@cbm.csic.es.; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain. jmredondo@cbm.csic.es., Campanero MR; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. mcampanero@cbm.csic.es.; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain. mcampanero@cbm.csic.es.
Source: Nature communications [Nat Commun] 2026 Jul 06; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fibronectin-induced overactivation of α<subscript>V</subscript>β<subscript>3</subscript>-PI3K-PIP3-PDK1-ILK signaling drives aortic disease in Marfan syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Alarcón-Ruiz+I%22">Alarcón-Ruiz I</searchLink>; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ruiz-Rodríguez+MJ%22">Ruiz-Rodríguez MJ</searchLink>; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Surgery (Cardiac), Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Martínez-Martínez+S%22">Martínez-Martínez S</searchLink>; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Toral+M%22">Toral M</searchLink>; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Martín-Bermejo+N%22">Martín-Bermejo N</searchLink>; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Mateos-García+S%22">Mateos-García S</searchLink>; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gil-Ruiz+T%22">Gil-Ruiz T</searchLink>; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Herrero-Galán+E%22">Herrero-Galán E</searchLink>; Molecular Mechanics of the Cardiovascular System, CNIC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Méndez-Olivares+MJ%22">Méndez-Olivares MJ</searchLink>; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López-Maderuelo+D%22">López-Maderuelo D</searchLink>; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Microscopy and Dynamic Imaging Unit, CNIC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gutiérrez-Martínez+C%22">Gutiérrez-Martínez C</searchLink>; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Clemente+C%22">Clemente C</searchLink>; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Clemente-Manteca+A%22">Clemente-Manteca A</searchLink>; Molecular Mechanics of the Cardiovascular System, CNIC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22H-Alcántara+A%22">H-Alcántara A</searchLink>; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Guala+A%22">Guala A</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Cardiology, Hospital Universitari Vall d'Hebron & Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Evangelista+A%22">Evangelista A</searchLink>; Teknon Medical Centre-Quironsalud, Heart Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Teixido-Tura+G%22">Teixido-Tura G</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Cardiology, Hospital Universitari Vall d'Hebron & Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Puyol+D%22">Rodríguez-Puyol D</searchLink>; Department of Medicine, Universidad de Alcalá de Henares & Nephrology Department, Hospital Príncipe de Asturias, Alcalá de Henares; Instituto Ramon y Cajal de Investigación Sanitaria (IRYCIS), Fundación Renal Iñigo Álvarez de Toledo (FRIAT) & RICOR from Instituto de Salud Carlos III and NOVELREN from Comunidad de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Nistal+JF%22">Nistal JF</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Cardiovascular Surgery, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Alegre-Cebollada+J%22">Alegre-Cebollada J</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Molecular Mechanics of the Cardiovascular System, CNIC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vázquez+J%22">Vázquez J</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Cardiovascular Proteomics, CNIC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Duarte+J%22">Duarte J</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Redondo+JM%22">Redondo JM</searchLink>; Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. jmredondo@cbm.csic.es.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. jmredondo@cbm.csic.es.; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain. jmredondo@cbm.csic.es.<br /><searchLink fieldCode="AU" term="%22Campanero+MR%22">Campanero MR</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. mcampanero@cbm.csic.es.; Tissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain. mcampanero@cbm.csic.es.
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