CD4-directed nanoblades enable selective genome editing in CD4+ cells and HIV suppression in vitro and in vivo.
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| Title: | CD4-directed nanoblades enable selective genome editing in CD4+ cells and HIV suppression in vitro and in vivo. |
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| Authors: | Van Cleemput J; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. jolien.vancleemput@ugent.be.; Laboratory of Virology, Department of Translational Physiology, Infectiology, and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. jolien.vancleemput@ugent.be., De Cock M; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Biopharmaceutical Technology Unit, Department of Pharmaceutics, Faculty of Pharmaceutics, Ghent University, Ghent, Belgium., Verbeek R; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Laboratory of Virology, Department of Translational Physiology, Infectiology, and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Burg E; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Van den Eeckhout B; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Witkowski W; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., van Snippenberg W; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Stylianidou Z; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Brugger Galetic E; Laboratory of Virology, Department of Translational Physiology, Infectiology, and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Delporte M; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Bracke K; Laboratory for Translational Research of Obstructive Pulmonary Disease, Department of Respiratory Medicine, Ghent University Hospital and Ghent University, Ghent, Belgium., Gerlo S; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. |
| Source: | EMBO molecular medicine [EMBO Mol Med] 2026 Jul 06. Date of Electronic Publication: 2026 Jul 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42410265 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: CD4-directed nanoblades enable selective genome editing in CD4<superscript>+</superscript> cells and HIV suppression in vitro and in vivo. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Van+Cleemput+J%22">Van Cleemput J</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. jolien.vancleemput@ugent.be.; Laboratory of Virology, Department of Translational Physiology, Infectiology, and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. jolien.vancleemput@ugent.be.<br /><searchLink fieldCode="AU" term="%22De+Cock+M%22">De Cock M</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Biopharmaceutical Technology Unit, Department of Pharmaceutics, Faculty of Pharmaceutics, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Verbeek+R%22">Verbeek R</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Laboratory of Virology, Department of Translational Physiology, Infectiology, and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.<br /><searchLink fieldCode="AU" term="%22Burg+E%22">Burg E</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+den+Eeckhout+B%22">Van den Eeckhout B</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Witkowski+W%22">Witkowski W</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22van+Snippenberg+W%22">van Snippenberg W</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Stylianidou+Z%22">Stylianidou Z</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Brugger+Galetic+E%22">Brugger Galetic E</searchLink>; Laboratory of Virology, Department of Translational Physiology, Infectiology, and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.<br /><searchLink fieldCode="AU" term="%22Delporte+M%22">Delporte M</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Bracke+K%22">Bracke K</searchLink>; Laboratory for Translational Research of Obstructive Pulmonary Disease, Department of Respiratory Medicine, Ghent University Hospital and Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Gerlo+S%22">Gerlo S</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Vandekerckhove+L%22">Vandekerckhove L</searchLink>; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101487380%22">EMBO molecular medicine</searchLink> [EMBO Mol Med] 2026 Jul 06. <i>Date of Electronic Publication: </i>2026 Jul 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101487380 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-4684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217574676%22">17574676 </searchLink><i>NLM ISO Abbreviation: </i>EMBO Mol Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42410265 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s44321-026-00481-x Languages: – Code: eng Text: English Titles: – TitleFull: CD4-directed nanoblades enable selective genome editing in CD4+ cells and HIV suppression in vitro and in vivo. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Van Cleemput J – PersonEntity: Name: NameFull: De Cock M – PersonEntity: Name: NameFull: Verbeek R – PersonEntity: Name: NameFull: Burg E – PersonEntity: Name: NameFull: Van den Eeckhout B – PersonEntity: Name: NameFull: Witkowski W – PersonEntity: Name: NameFull: van Snippenberg W – PersonEntity: Name: NameFull: Stylianidou Z – PersonEntity: Name: NameFull: Brugger Galetic E – PersonEntity: Name: NameFull: Delporte M – PersonEntity: Name: NameFull: Bracke K – PersonEntity: Name: NameFull: Gerlo S – PersonEntity: Name: NameFull: Vandekerckhove L IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 07 Text: 2026 Jul 06 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1757-4684 Titles: – TitleFull: EMBO molecular medicine Type: main |
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