Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process.

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Title: Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process.
Authors: Salminen A; Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland. antero.salminen@uef.fi., Kaarniranta K; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.; Department of Ophthalmology, Kuopio University Hospital, P.O. Box 100, 70029 KYS, Kuopio, Finland., Kauppinen A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Source: Biogerontology [Biogerontology] 2026 Jul 07; Vol. 27 (4). Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article; Review
Journal Info: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 100930043 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6768 (Electronic) Linking ISSN: 13895729 NLM ISO Abbreviation: Biogerontology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Salminen+A%22">Salminen A</searchLink>; Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland. antero.salminen@uef.fi.<br /><searchLink fieldCode="AU" term="%22Kaarniranta+K%22">Kaarniranta K</searchLink>; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.; Department of Ophthalmology, Kuopio University Hospital, P.O. Box 100, 70029 KYS, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Kauppinen+A%22">Kauppinen A</searchLink>; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
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  Data: <searchLink fieldCode="JN" term="%22100930043%22">Biogerontology</searchLink> [Biogerontology] 2026 Jul 07; Vol. 27 (4). <i>Date of Electronic Publication: </i>2026 Jul 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Kluwer+Academic%22">Kluwer Academic </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>100930043 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-6768 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213895729%22">13895729 </searchLink><i>NLM ISO Abbreviation: </i>Biogerontology <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1007/s10522-026-10470-9
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      – Code: eng
        Text: English
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      – TitleFull: Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process.
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            NameFull: Salminen A
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            NameFull: Kaarniranta K
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            NameFull: Kauppinen A
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          Dates:
            – D: 07
              M: 07
              Text: 2026 Jul 07
              Type: published
              Y: 2026
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              Value: 1573-6768
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              Value: 27
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              Value: 4
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            – TitleFull: Biogerontology
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