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Prime-edited isogenic hiPSC-derived cardiomyocyte model of short QT syndrome type 3 reveals electrophysiological phenotypes and differential drug responses.

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Title: Prime-edited isogenic hiPSC-derived cardiomyocyte model of short QT syndrome type 3 reveals electrophysiological phenotypes and differential drug responses.
Authors: Kim MW; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea., Park JH; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea., Lee M; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea., Lee SG; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea., Oh JS; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea., Park S; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea., Jeong Y; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea., Kim Y; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea., Shin H; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea., Kim J; Department of Physiology, College of Medicine, Soonchunhyang University, Cheonan, 31151, Republic of Korea; Institute for Molecular Metabolism Innovation, Soonchunhyang University, Asan, 31538, Republic of Korea., Kim CY; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea. Electronic address: vivavet@konkuk.ac.kr., Chung HM; Department of Stem Cell Biology, College of Medicine, Konkuk University, Seoul, 05029, Republic of Korea. Electronic address: hmchung@kku.ac.kr.
Source: Life sciences [Life Sci] 2026 Jul 07; Vol. 402, pp. 124573. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prime-edited isogenic hiPSC-derived cardiomyocyte model of short QT syndrome type 3 reveals electrophysiological phenotypes and differential drug responses.
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  Data: <searchLink fieldCode="AU" term="%22Kim+MW%22">Kim MW</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+JH%22">Park JH</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+M%22">Lee M</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SG%22">Lee SG</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+JS%22">Oh JS</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+Y%22">Jeong Y</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+Y%22">Kim Y</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shin+H%22">Shin H</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Physiology, College of Medicine, Soonchunhyang University, Cheonan, 31151, Republic of Korea; Institute for Molecular Metabolism Innovation, Soonchunhyang University, Asan, 31538, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+CY%22">Kim CY</searchLink>; College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea. Electronic address: vivavet@konkuk.ac.kr.<br /><searchLink fieldCode="AU" term="%22Chung+HM%22">Chung HM</searchLink>; Department of Stem Cell Biology, College of Medicine, Konkuk University, Seoul, 05029, Republic of Korea. Electronic address: hmchung@kku.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%220375521%22">Life sciences</searchLink> [Life Sci] 2026 Jul 07; Vol. 402, pp. 124573. <i>Date of Electronic Publication: </i>2026 Jul 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0375521 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0631 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200243205%22">00243205 </searchLink><i>NLM ISO Abbreviation: </i>Life Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.lfs.2026.124573
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              Text: 2026 Jul 07
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