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Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin.

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Title: Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin.
Authors: Li D; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Wang X; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA., Hao H; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA., Eden J; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA., Hu B; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Walsh EE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; University of Victoria Genome BC Proteomic Centre, Victoria, BC, Canada., Parson MAH; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA., Hamill S; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA., Li Y; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA., Chen G; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA., Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; University of Victoria Genome BC Proteomic Centre, Victoria, BC, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada., De Camilli P; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Electronic address: pietro.decamilli@yale.edu., Reinisch KM; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: karin.reinisch@yale.edu.
Source: Molecular cell [Mol Cell] 2026 Jul 16; Vol. 86 (14), pp. 2843-2857.e10. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
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  Data: Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin.
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  Data: <searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hao+H%22">Hao H</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Eden+J%22">Eden J</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+EE%22">Walsh EE</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; University of Victoria Genome BC Proteomic Centre, Victoria, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Parson+MAH%22">Parson MAH</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hamill+S%22">Hamill S</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Burke+JE%22">Burke JE</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; University of Victoria Genome BC Proteomic Centre, Victoria, BC, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22De+Camilli+P%22">De Camilli P</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Electronic address: pietro.decamilli@yale.edu.<br /><searchLink fieldCode="AU" term="%22Reinisch+KM%22">Reinisch KM</searchLink>; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: karin.reinisch@yale.edu.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2026 Jul 16; Vol. 86 (14), pp. 2843-2857.e10. <i>Date of Electronic Publication: </i>2026 Jul 07.
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