Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin.
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| Title: | Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin. |
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| Authors: | Li D; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Wang X; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA., Hao H; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA., Eden J; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA., Hu B; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Walsh EE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; University of Victoria Genome BC Proteomic Centre, Victoria, BC, Canada., Parson MAH; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA., Hamill S; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA., Li Y; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA., Chen G; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA., Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; University of Victoria Genome BC Proteomic Centre, Victoria, BC, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada., De Camilli P; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Electronic address: pietro.decamilli@yale.edu., Reinisch KM; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: karin.reinisch@yale.edu. |
| Source: | Molecular cell [Mol Cell] 2026 Jul 16; Vol. 86 (14), pp. 2843-2857.e10. Date of Electronic Publication: 2026 Jul 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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