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Pharmacologic activity, safety, and preliminary efficacy of GEN3009, a CD37-targeting DuoHexaBody, in relapsed or refractory B-cell non-Hodgkin's lymphoma.

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Title: Pharmacologic activity, safety, and preliminary efficacy of GEN3009, a CD37-targeting DuoHexaBody, in relapsed or refractory B-cell non-Hodgkin's lymphoma.
Authors: Awan FT; UT Southwestern Medical Center, Dallas, Texas, USA Farrukh.Awan@UTSouthwestern.edu., Gamse JT; Genmab US Inc, Plainsboro, New Jersey, USA., Overdijk MB; Genmab BV, Utrecht, The Netherlands., Breij ECW; Genmab BV, Utrecht, The Netherlands., Jure-Kunkel M; Genmab US Inc, Plainsboro, New Jersey, USA., Sanghavi K; Genmab US Inc, Plainsboro, New Jersey, USA., Brady LK; Genmab US Inc, Plainsboro, New Jersey, USA., Guan M; Genmab US Inc, Plainsboro, New Jersey, USA., Verbrugge I; Genmab BV, Utrecht, The Netherlands., Chen J; Genmab US Inc, Plainsboro, New Jersey, USA., Gong N; Genmab US Inc, Plainsboro, New Jersey, USA., Gillespie M; Genmab US Inc, Plainsboro, New Jersey, USA., Tees M; Colorado Blood Cancer Institute/Sarah Cannon Research Institute, Denver, Colorado, USA., Gallogly M; Seidman Cancer Center, University Hospitals of Cleveland, Cleveland, Ohio, USA., Hutchings M; Rigshospitalet, Copenhagen, Denmark.; University of Copenhagen, Copenhagen, Denmark., Christensen JH; Odense University Hospital, Odense, Denmark., Sureda A; Clinical Hematology Department, Institut Català d'Oncologia - L'Hospitalet, IDIBELL, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain., Cordoba R; Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain., Ahmed S; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Woei-A-Jin FJSH; University Hospitals Leuven, Leuven, Belgium., Abrisqueta P; Hospital Universitario Vall d'Hebron, Barcelona, Spain., Giné E; Hospital Clínic IDIBAPS, Barcelona, Spain., Roost Clausen M; Vejle Hospital, Vejle, Denmark., Bhat SA; Division of Hematology, The Ohio State University, Columbus, Ohio, USA., Gopal AK; Fred Hutchinson Cancer Center at UW Medical Center - Northwest, Seattle, Washington, USA., Chamuleau MED; On behalf of the Lunenburg Lymphoma Phase I/II Consortium-HOVON/LLPC, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Jul 07; Vol. 14 (7). Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Pharmacologic activity, safety, and preliminary efficacy of GEN3009, a CD37-targeting DuoHexaBody, in relapsed or refractory B-cell non-Hodgkin's lymphoma.
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  Data: <searchLink fieldCode="AU" term="%22Awan+FT%22">Awan FT</searchLink>; UT Southwestern Medical Center, Dallas, Texas, USA Farrukh.Awan@UTSouthwestern.edu.<br /><searchLink fieldCode="AU" term="%22Gamse+JT%22">Gamse JT</searchLink>; Genmab US Inc, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Overdijk+MB%22">Overdijk MB</searchLink>; Genmab BV, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Breij+ECW%22">Breij ECW</searchLink>; Genmab BV, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jure-Kunkel+M%22">Jure-Kunkel M</searchLink>; Genmab US Inc, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Sanghavi+K%22">Sanghavi K</searchLink>; Genmab US Inc, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Brady+LK%22">Brady LK</searchLink>; Genmab US Inc, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Guan+M%22">Guan M</searchLink>; Genmab US Inc, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Verbrugge+I%22">Verbrugge I</searchLink>; Genmab BV, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Genmab US Inc, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Gong+N%22">Gong N</searchLink>; Genmab US Inc, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Gillespie+M%22">Gillespie M</searchLink>; Genmab US Inc, Plainsboro, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Tees+M%22">Tees M</searchLink>; Colorado Blood Cancer Institute/Sarah Cannon Research Institute, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Gallogly+M%22">Gallogly M</searchLink>; Seidman Cancer Center, University Hospitals of Cleveland, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Hutchings+M%22">Hutchings M</searchLink>; Rigshospitalet, Copenhagen, Denmark.; University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Christensen+JH%22">Christensen JH</searchLink>; Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Sureda+A%22">Sureda A</searchLink>; Clinical Hematology Department, Institut Català d'Oncologia - L'Hospitalet, IDIBELL, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cordoba+R%22">Cordoba R</searchLink>; Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ahmed+S%22">Ahmed S</searchLink>; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Woei-A-Jin+FJSH%22">Woei-A-Jin FJSH</searchLink>; University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Abrisqueta+P%22">Abrisqueta P</searchLink>; Hospital Universitario Vall d'Hebron, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Giné+E%22">Giné E</searchLink>; Hospital Clínic IDIBAPS, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Roost+Clausen+M%22">Roost Clausen M</searchLink>; Vejle Hospital, Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22Bhat+SA%22">Bhat SA</searchLink>; Division of Hematology, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Gopal+AK%22">Gopal AK</searchLink>; Fred Hutchinson Cancer Center at UW Medical Center - Northwest, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Chamuleau+MED%22">Chamuleau MED</searchLink>; On behalf of the Lunenburg Lymphoma Phase I/II Consortium-HOVON/LLPC, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2026 Jul 07; Vol. 14 (7). <i>Date of Electronic Publication: </i>2026 Jul 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jitc-2025-014311
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        Text: English
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      – TitleFull: Pharmacologic activity, safety, and preliminary efficacy of GEN3009, a CD37-targeting DuoHexaBody, in relapsed or refractory B-cell non-Hodgkin's lymphoma.
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              Text: 2026 Jul 07
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