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Flucloxacillin plasma and urinary concentrations with and without probenecid and urinary biomarker profiles in healthy volunteers.

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Title: Flucloxacillin plasma and urinary concentrations with and without probenecid and urinary biomarker profiles in healthy volunteers.
Authors: Legg A; Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia., Boast A; Antimicrobials Group, Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Infectious Diseases Department, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia., Piera K; Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia., Liu X; University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia., Wallis SC; University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia., McCarthy J; Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia., Davis JS; Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.; School of Medicine and Public Health and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia., Tong SYC; Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Gwee A; Antimicrobials Group, Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Infectious Diseases Department, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia., Roberts JA; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.; Herston Infectious Diseases Institute, Herston, Queensland, Australia.; Division of Anesthesia Critical Care and Emergency and Pain Medicine, UR UM 103, University of Montpellier, Nimes University Hospital, Nimes, France.
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2026 Jul 07. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
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  Data: Flucloxacillin plasma and urinary concentrations with and without probenecid and urinary biomarker profiles in healthy volunteers.
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  Data: <searchLink fieldCode="AU" term="%22Legg+A%22">Legg A</searchLink>; Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Boast+A%22">Boast A</searchLink>; Antimicrobials Group, Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Infectious Diseases Department, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Piera+K%22">Piera K</searchLink>; Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Wallis+SC%22">Wallis SC</searchLink>; University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22McCarthy+J%22">McCarthy J</searchLink>; Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Davis+JS%22">Davis JS</searchLink>; Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.; School of Medicine and Public Health and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.<br /><searchLink fieldCode="AU" term="%22Tong+SYC%22">Tong SYC</searchLink>; Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Gwee+A%22">Gwee A</searchLink>; Antimicrobials Group, Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Infectious Diseases Department, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Roberts+JA%22">Roberts JA</searchLink>; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.; Herston Infectious Diseases Institute, Herston, Queensland, Australia.; Division of Anesthesia Critical Care and Emergency and Pain Medicine, UR UM 103, University of Montpellier, Nimes University Hospital, Nimes, France.
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        Value: 10.1002/bcp.70663
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            – D: 07
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              Text: 2026 Jul 07
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              Y: 2026
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