A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration.

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Title: A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration.
Authors: Dehio P; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland.; Institute of Science and Technology Austria, Klosterneuburg, Austria., Michard C; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland., Yam-Puc JC; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Martí I Líndez AA; Department of Medicine, CITIID, University of Cambridge, Cambridge, UK., Jandke A; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland., Unterstab G; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland., Fabre L; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland., Sauteur L; Microscopy Core Facility, Department of Biomedicine, University of Basel, Basel, Switzerland., Artinger M; Institute of Cell Biology and Immunology Thurgau, University of Konstanz, Kreuzlingen, Switzerland., Legler DF; Institute of Cell Biology and Immunology Thurgau, University of Konstanz, Kreuzlingen, Switzerland.; Theodor Kocher Institute, University of Bern, Bern, Switzerland.; Faculty of Biology, University of Konstanz, Konstanz, Germany., Sixt M; Institute of Science and Technology Austria, Klosterneuburg, Austria., Schaefer T; Department of Biomedicine, Cancer- and Immunobiology, University of Basel, Basel, Switzerland., Wymann MP; Department of Biomedicine, Cancer- and Immunobiology, University of Basel, Basel, Switzerland., Okkenhaug K; Department of Pathology, University of Cambridge, Cambridge, UK., Soldati T; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland., Mehling M; Department of Biomedicine, Translational Neuroimmunology, University of Basel and University Hospital Basel, Basel, Switzerland., Hess C; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland. ch818@cam.ac.uk.; Department of Medicine, CITIID, University of Cambridge, Cambridge, UK. ch818@cam.ac.uk.
Source: EMBO reports [EMBO Rep] 2026 Jul 07. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
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  Data: A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration.
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  Data: <searchLink fieldCode="AU" term="%22Dehio+P%22">Dehio P</searchLink>; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland.; Institute of Science and Technology Austria, Klosterneuburg, Austria.<br /><searchLink fieldCode="AU" term="%22Michard+C%22">Michard C</searchLink>; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Yam-Puc+JC%22">Yam-Puc JC</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Martí+I+Líndez+AA%22">Martí I Líndez AA</searchLink>; Department of Medicine, CITIID, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Jandke+A%22">Jandke A</searchLink>; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Unterstab+G%22">Unterstab G</searchLink>; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fabre+L%22">Fabre L</searchLink>; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sauteur+L%22">Sauteur L</searchLink>; Microscopy Core Facility, Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Artinger+M%22">Artinger M</searchLink>; Institute of Cell Biology and Immunology Thurgau, University of Konstanz, Kreuzlingen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Legler+DF%22">Legler DF</searchLink>; Institute of Cell Biology and Immunology Thurgau, University of Konstanz, Kreuzlingen, Switzerland.; Theodor Kocher Institute, University of Bern, Bern, Switzerland.; Faculty of Biology, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Sixt+M%22">Sixt M</searchLink>; Institute of Science and Technology Austria, Klosterneuburg, Austria.<br /><searchLink fieldCode="AU" term="%22Schaefer+T%22">Schaefer T</searchLink>; Department of Biomedicine, Cancer- and Immunobiology, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wymann+MP%22">Wymann MP</searchLink>; Department of Biomedicine, Cancer- and Immunobiology, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Okkenhaug+K%22">Okkenhaug K</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Soldati+T%22">Soldati T</searchLink>; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mehling+M%22">Mehling M</searchLink>; Department of Biomedicine, Translational Neuroimmunology, University of Basel and University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hess+C%22">Hess C</searchLink>; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland. ch818@cam.ac.uk.; Department of Medicine, CITIID, University of Cambridge, Cambridge, UK. ch818@cam.ac.uk.
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