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Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8+ T cells.

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Title: Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8+ T cells.
Authors: Frei J; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland., Eisel D; BioNTech SE, Mainz, Germany., Jarzebska NT; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland.; Faculty of Science, University of Zurich, Zurich, Switzerland., Mellett M; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland., Yener IG; BioNTech SE, Mainz, Germany.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany., Abdou MT; Institute of Immunobiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Gouttefangeas C; Institute of Immunology, University and University Hospital of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumour Therapies', University of Tübingen, Tübingen, Germany., Flatz L; Institute of Immunobiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.; Center for Dermatooncology, Department of Dermatology, Eberhard Karls University Tübingen, Tübingen, Germany., Diken M; BioNTech SE, Mainz, Germany.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany., Kündig TM; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland., Sahin U; BioNTech SE, Mainz, Germany. ugur.sahin@tron-mainz.de.; Helmholtz Institute (HI) TRON Mainz, Mainz, Germany. ugur.sahin@tron-mainz.de., Pascolo S; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland. steve.pascolo@usz.ch.; Faculty of Medicine, University of Zurich, Zurich, Switzerland. steve.pascolo@usz.ch.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Jul 07. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8<superscript>+</superscript> T cells.
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  Data: <searchLink fieldCode="AU" term="%22Frei+J%22">Frei J</searchLink>; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Eisel+D%22">Eisel D</searchLink>; BioNTech SE, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Jarzebska+NT%22">Jarzebska NT</searchLink>; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland.; Faculty of Science, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mellett+M%22">Mellett M</searchLink>; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Yener+IG%22">Yener IG</searchLink>; BioNTech SE, Mainz, Germany.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Abdou+MT%22">Abdou MT</searchLink>; Institute of Immunobiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gouttefangeas+C%22">Gouttefangeas C</searchLink>; Institute of Immunology, University and University Hospital of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumour Therapies', University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Flatz+L%22">Flatz L</searchLink>; Institute of Immunobiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.; Center for Dermatooncology, Department of Dermatology, Eberhard Karls University Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Diken+M%22">Diken M</searchLink>; BioNTech SE, Mainz, Germany.; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Kündig+TM%22">Kündig TM</searchLink>; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sahin+U%22">Sahin U</searchLink>; BioNTech SE, Mainz, Germany. ugur.sahin@tron-mainz.de.; Helmholtz Institute (HI) TRON Mainz, Mainz, Germany. ugur.sahin@tron-mainz.de.<br /><searchLink fieldCode="AU" term="%22Pascolo+S%22">Pascolo S</searchLink>; Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland. steve.pascolo@usz.ch.; Faculty of Medicine, University of Zurich, Zurich, Switzerland. steve.pascolo@usz.ch.
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  Data: <searchLink fieldCode="JN" term="%22101696896%22">Nature biomedical engineering</searchLink> [Nat Biomed Eng] 2026 Jul 07. <i>Date of Electronic Publication: </i>2026 Jul 07.
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              Text: 2026 Jul 07
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