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Largazole targets Musashi protein expression via miR-125b-5p and sensitizes triple-negative breast cancer cells to radiation.

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Title: Largazole targets Musashi protein expression via miR-125b-5p and sensitizes triple-negative breast cancer cells to radiation.
Authors: Gurke Brücksken KA; Department of Radiation Oncology, University Hospital Münster, Münster, Germany., Lappe L; Department of Radiation Oncology, University Hospital Münster, Münster, Germany., Chen QY; Department of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL, United States., Luesch H; Department of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL, United States.; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Korsching E; Cancer and Complex Systems Research Group, Medical Faculty, University of Münster, Münster, Germany., Reichstein L; Department of Radiation Oncology, University Hospital Münster, Münster, Germany., Marzi A; Biomedical Technology Center, Medical Faculty, University of Münster, Münster, Germany., Espinoza-Sánchez NA; Department of Radiation Oncology, University Hospital Münster, Münster, Germany.; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Habig T; Department of Radiation Oncology, University Hospital Münster, Münster, Germany., Fuentes-Pananá EM; Research Unit on Virology and Cancer, Children's Hospital of Mexico 'Federico Gómez', Mexico City, Mexico., Kemper B; Biomedical Technology Center, Medical Faculty, University of Münster, Münster, Germany., Tio J; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Götte M; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Eich HT; Department of Radiation Oncology, University Hospital Münster, Münster, Germany., Greve B; Department of Radiation Oncology, University Hospital Münster, Münster, Germany., Troschel FM; Department of Radiation Oncology, University Hospital Münster, Münster, Germany.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Jun 23; Vol. 17, pp. 1745079. Date of Electronic Publication: 2026 Jun 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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  Data: Largazole targets Musashi protein expression via miR-125b-5p and sensitizes triple-negative breast cancer cells to radiation.
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