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Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.

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Title: Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.
Authors: Sasannia S; Department of Neurology (S.S., R.L., L.K., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD (S.S., H.-G.S., P.v.Z., L.K.)., Matsyuk M; Neurocritical Care Division, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Hospital, Baltimore, MD (M.M., P.A.N.)., Wang S; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD (S.W., J.Z., J.L.P.)., Zhang J; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD (S.W., J.Z., J.L.P.)., Walker KA; Intramural Research Program, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD (K.A.W.)., Shin HG; Russell H. Morgan Department of Radiology and Radiological Science (H.-G.S., P.v.Z.)Johns Hopkins University School of Medicine, Baltimore, MD.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD (S.S., H.-G.S., P.v.Z., L.K.)., Leigh R; Department of Neurology (S.S., R.L., L.K., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD., Prince JL; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD (S.W., J.Z., J.L.P.)., Becker LC; Department of Medicine (L.C.B., L.R.Y., D.V., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD., Yanek LR; Department of Medicine (L.C.B., L.R.Y., D.V., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD., Armstrong NJ; Department of Mathematics and Statistics, Curtin University, Perth, WA, Australia (N.J.A.)., van Zijl P; Russell H. Morgan Department of Radiology and Radiological Science (H.-G.S., P.v.Z.)Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Biomedical Engineering (P.v.Z.)Johns Hopkins University School of Medicine, Baltimore, MD.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD (S.S., H.-G.S., P.v.Z., L.K.)., Vaidya D; Department of Medicine (L.C.B., L.R.Y., D.V., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD., Knutsson L; Department of Neurology (S.S., R.L., L.K., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD (S.S., H.-G.S., P.v.Z., L.K.).; Department of Medical Radiation Physics, Lund University, Sweden (L.K.)., Nyquist PA; Department of Neurology (S.S., R.L., L.K., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Medicine (L.C.B., L.R.Y., D.V., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Neurosurgery (P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; Neurocritical Care Division, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Hospital, Baltimore, MD (M.M., P.A.N.).
Source: Stroke [Stroke] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Sasannia+S%22">Sasannia S</searchLink>; Department of Neurology (S.S., R.L., L.K., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD (S.S., H.-G.S., P.v.Z., L.K.).<br /><searchLink fieldCode="AU" term="%22Matsyuk+M%22">Matsyuk M</searchLink>; Neurocritical Care Division, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Hospital, Baltimore, MD (M.M., P.A.N.).<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD (S.W., J.Z., J.L.P.).<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD (S.W., J.Z., J.L.P.).<br /><searchLink fieldCode="AU" term="%22Walker+KA%22">Walker KA</searchLink>; Intramural Research Program, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD (K.A.W.).<br /><searchLink fieldCode="AU" term="%22Shin+HG%22">Shin HG</searchLink>; Russell H. Morgan Department of Radiology and Radiological Science (H.-G.S., P.v.Z.)Johns Hopkins University School of Medicine, Baltimore, MD.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD (S.S., H.-G.S., P.v.Z., L.K.).<br /><searchLink fieldCode="AU" term="%22Leigh+R%22">Leigh R</searchLink>; Department of Neurology (S.S., R.L., L.K., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Prince+JL%22">Prince JL</searchLink>; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD (S.W., J.Z., J.L.P.).<br /><searchLink fieldCode="AU" term="%22Becker+LC%22">Becker LC</searchLink>; Department of Medicine (L.C.B., L.R.Y., D.V., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Yanek+LR%22">Yanek LR</searchLink>; Department of Medicine (L.C.B., L.R.Y., D.V., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Armstrong+NJ%22">Armstrong NJ</searchLink>; Department of Mathematics and Statistics, Curtin University, Perth, WA, Australia (N.J.A.).<br /><searchLink fieldCode="AU" term="%22van+Zijl+P%22">van Zijl P</searchLink>; Russell H. Morgan Department of Radiology and Radiological Science (H.-G.S., P.v.Z.)Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Biomedical Engineering (P.v.Z.)Johns Hopkins University School of Medicine, Baltimore, MD.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD (S.S., H.-G.S., P.v.Z., L.K.).<br /><searchLink fieldCode="AU" term="%22Vaidya+D%22">Vaidya D</searchLink>; Department of Medicine (L.C.B., L.R.Y., D.V., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Knutsson+L%22">Knutsson L</searchLink>; Department of Neurology (S.S., R.L., L.K., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD (S.S., H.-G.S., P.v.Z., L.K.).; Department of Medical Radiation Physics, Lund University, Sweden (L.K.).<br /><searchLink fieldCode="AU" term="%22Nyquist+PA%22">Nyquist PA</searchLink>; Department of Neurology (S.S., R.L., L.K., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Medicine (L.C.B., L.R.Y., D.V., P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; Department of Neurosurgery (P.A.N.)Johns Hopkins University School of Medicine, Baltimore, MD.; Neurocritical Care Division, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Hospital, Baltimore, MD (M.M., P.A.N.).
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        Value: 10.1161/STROKEAHA.125.054810
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        Text: English
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      – TitleFull: Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.
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              Text: 2026 Jul 08
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              Y: 2026
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