Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress.

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Title: Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress.
Authors: Gigas J; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.; Medical Scientist Training Program, University of Rochester, Rochester, NY, 14627, USA., Meadow ME; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.; Medical Scientist Training Program, University of Rochester, Rochester, NY, 14627, USA., Guo J; Department of Biology, University of Rochester, Rochester, NY, 14627, USA., Lan C; Department of Biology, University of Rochester, Rochester, NY, 14627, USA., Hillpot E; Department of Biology, University of Rochester, Rochester, NY, 14627, USA., Martinez JC; Department of Biology, University of Rochester, Rochester, NY, 14627, USA., Tombline G; Department of Biology, University of Rochester, Rochester, NY, 14627, USA., Bellomio P; Department of Biology, University of Rochester, Rochester, NY, 14627, USA., Rivera-Almodóvar V; Department of Biology, University of Rochester, Rochester, NY, 14627, USA., Welle KA; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, 14627, USA., Swovick K; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, 14627, USA., Hryhorenko JR; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, 14627, USA., Ablaeva J; Department of Biology, University of Rochester, Rochester, NY, 14627, USA., Ghaemmaghami S; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, 14627, USA., Seluanov A; Department of Biology, University of Rochester, Rochester, NY, 14627, USA. andrei.seluanov@rochester.edu.; Department of Medicine, University of Rochester, Rochester, NY, 14627, USA. andrei.seluanov@rochester.edu., Gorbunova V; Department of Biology, University of Rochester, Rochester, NY, 14627, USA. vera.gorbunova@rochester.edu.; Department of Medicine, University of Rochester, Rochester, NY, 14627, USA. vera.gorbunova@rochester.edu.
Source: GeroScience [Geroscience] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
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  Data: Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress.
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  Data: <searchLink fieldCode="AU" term="%22Gigas+J%22">Gigas J</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.; Medical Scientist Training Program, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Meadow+ME%22">Meadow ME</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.; Medical Scientist Training Program, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Lan+C%22">Lan C</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Hillpot+E%22">Hillpot E</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+JC%22">Martinez JC</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Tombline+G%22">Tombline G</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Bellomio+P%22">Bellomio P</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Rivera-Almodóvar+V%22">Rivera-Almodóvar V</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Welle+KA%22">Welle KA</searchLink>; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Swovick+K%22">Swovick K</searchLink>; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Hryhorenko+JR%22">Hryhorenko JR</searchLink>; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Ablaeva+J%22">Ablaeva J</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Ghaemmaghami+S%22">Ghaemmaghami S</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA.; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, 14627, USA.<br /><searchLink fieldCode="AU" term="%22Seluanov+A%22">Seluanov A</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA. andrei.seluanov@rochester.edu.; Department of Medicine, University of Rochester, Rochester, NY, 14627, USA. andrei.seluanov@rochester.edu.<br /><searchLink fieldCode="AU" term="%22Gorbunova+V%22">Gorbunova V</searchLink>; Department of Biology, University of Rochester, Rochester, NY, 14627, USA. vera.gorbunova@rochester.edu.; Department of Medicine, University of Rochester, Rochester, NY, 14627, USA. vera.gorbunova@rochester.edu.
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              Text: 2026 Jul 08
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