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mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity.

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Title: mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity.
Authors: Zeng Y; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Xu J; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Wang J; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Xue L; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Liu J; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Geisler HC; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Ma X; Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, China., Melamed JR; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Shi Q; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Padilla MS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Luo Z; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Zhu J; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Thatte AS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Figueroa-Espada CG; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Ang MJY; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Republic of Singapore, Singapore 138668, Singapore., Murray AM; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Yamagata HM; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Kim D; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Metzloff AE; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Weissman D; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA 19104.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Precision Engineering for Health, University of Pennsylvania, Philadelphia, PA 19104.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jul 14; Vol. 123 (28), pp. e2525718123. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity.
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  Data: <searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Xue+L%22">Xue L</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Geisler+HC%22">Geisler HC</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, China.<br /><searchLink fieldCode="AU" term="%22Melamed+JR%22">Melamed JR</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Shi+Q%22">Shi Q</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Padilla+MS%22">Padilla MS</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Luo+Z%22">Luo Z</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Thatte+AS%22">Thatte AS</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Figueroa-Espada+CG%22">Figueroa-Espada CG</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Ang+MJY%22">Ang MJY</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Republic of Singapore, Singapore 138668, Singapore.<br /><searchLink fieldCode="AU" term="%22Murray+AM%22">Murray AM</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Yamagata+HM%22">Yamagata HM</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Metzloff+AE%22">Metzloff AE</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Weissman+D%22">Weissman D</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Mitchell+MJ%22">Mitchell MJ</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA 19104.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Precision Engineering for Health, University of Pennsylvania, Philadelphia, PA 19104.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Jul 14; Vol. 123 (28), pp. e2525718123. <i>Date of Electronic Publication: </i>2026 Jul 08.
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