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EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma.

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Title: EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma.
Authors: Nayab A; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mughal N; Department of Surgery, Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi 74800, Pakistan.; Department of Biological and Biomedical Sciences, Aga Khan University Hospital, Karachi 74800, Pakistan., Angez M; Department of Surgery, Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi 74800, Pakistan., Xing S; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Burma AM; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Balla H; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Kizilbash SH; Department of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA., Yang X; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Maqbool MA; Department of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA., Arain F; Department of Biological and Biomedical Sciences, Aga Khan University Hospital, Karachi 74800, Pakistan., Hussain A; Department of Biological and Biomedical Sciences, Aga Khan University Hospital, Karachi 74800, Pakistan., Amir S; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Singh D; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Karmali A; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Somani S; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Patel TR; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Patel A; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hatanpaa KJ; Department of Pathology, University of Texas Southwestern Medical Center, Dallas TX 75390, USA., Youssef M; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Shaikh N; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Ye C; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Zhao D; Departments of Biomedical Engineering and Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA., Burma S; Departments of Neurosurgery and Biochemistry & Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA., Majd NK; Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Saleh M; Department of Hematology-Oncology, Aga Khan University Hospital, Nairobi, Kenya., Charest A; Cancer Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Miller CR; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 35233, USA., Nabors LB; O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Kataru MS; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Tolbert CE; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Jimenez F; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Enam SA; Department of Surgery, Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi 74800, Pakistan., Habib AA; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Harold C. Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center, Dallas TX 75390, USA.; Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; VA North Texas Health Care System, Dallas TX 75216, USA., Guo G; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Harold C. Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center, Dallas TX 75390, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Jul 08; Vol. 18 (857), pp. eadx8398. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma.
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Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Majd+NK%22">Majd NK</searchLink>; Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Saleh+M%22">Saleh M</searchLink>; Department of Hematology-Oncology, Aga Khan University Hospital, Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Charest+A%22">Charest A</searchLink>; Cancer Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Miller+CR%22">Miller CR</searchLink>; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Nabors+LB%22">Nabors LB</searchLink>; O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Kataru+MS%22">Kataru MS</searchLink>; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Tolbert+CE%22">Tolbert CE</searchLink>; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Jimenez+F%22">Jimenez F</searchLink>; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Enam+SA%22">Enam SA</searchLink>; Department of Surgery, Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi 74800, Pakistan.<br /><searchLink fieldCode="AU" term="%22Habib+AA%22">Habib AA</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Harold C. Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center, Dallas TX 75390, USA.; Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; VA North Texas Health Care System, Dallas TX 75216, USA.<br /><searchLink fieldCode="AU" term="%22Guo+G%22">Guo G</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Harold C. Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center, Dallas TX 75390, USA.
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