EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma.
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| Title: | EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma. |
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| Authors: | Nayab A; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mughal N; Department of Surgery, Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi 74800, Pakistan.; Department of Biological and Biomedical Sciences, Aga Khan University Hospital, Karachi 74800, Pakistan., Angez M; Department of Surgery, Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi 74800, Pakistan., Xing S; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Burma AM; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Balla H; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Kizilbash SH; Department of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA., Yang X; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Maqbool MA; Department of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA., Arain F; Department of Biological and Biomedical Sciences, Aga Khan University Hospital, Karachi 74800, Pakistan., Hussain A; Department of Biological and Biomedical Sciences, Aga Khan University Hospital, Karachi 74800, Pakistan., Amir S; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Singh D; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Karmali A; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Somani S; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Patel TR; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Patel A; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hatanpaa KJ; Department of Pathology, University of Texas Southwestern Medical Center, Dallas TX 75390, USA., Youssef M; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Shaikh N; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Ye C; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Zhao D; Departments of Biomedical Engineering and Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA., Burma S; Departments of Neurosurgery and Biochemistry & Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA., Majd NK; Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Saleh M; Department of Hematology-Oncology, Aga Khan University Hospital, Nairobi, Kenya., Charest A; Cancer Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Miller CR; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 35233, USA., Nabors LB; O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Kataru MS; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Tolbert CE; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Jimenez F; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Enam SA; Department of Surgery, Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi 74800, Pakistan., Habib AA; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Harold C. Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center, Dallas TX 75390, USA.; Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; VA North Texas Health Care System, Dallas TX 75216, USA., Guo G; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Harold C. Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center, Dallas TX 75390, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Jul 08; Vol. 18 (857), pp. eadx8398. Date of Electronic Publication: 2026 Jul 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adx8398 |
