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Setmelanotide for the Treatment of Acquired Hypothalamic Obesity.

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Title: Setmelanotide for the Treatment of Acquired Hypothalamic Obesity.
Authors: Miller JL; Pediatric Endocrinology, Department of Pediatrics, College of Medicine, University of Florida, Gainesville., van Santen HM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands., Phillips SA; Rady Children's Hospital, San Diego.; Department of Pediatrics, Division of Endocrinology, University of California, San Diego, San Diego., Hamilton J; Division of Endocrinology, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto., Aberle J; University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sathyapalan T; Hull York Medical School, Hull, United Kingdom., Mohamed Z; Birmingham Women's and Children's, Birmingham, United Kingdom., McCormack SE; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia.; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Shoemaker AH; Vanderbilt University Medical Center, Nashville., Kelsey MM; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora., Ghalib L; Ohio State Wexner Medical Center, Columbus., Stalla G; Medicover Neuroendokrinologie Medizinisches Versorgungszentrum, Münster, Germany., Thaker VV; Division of Molecular Genetics, Columbia University Irving Medical Center, New York.; Division of Pediatric Endocrinology, Department of Pediatrics, Columbia University Irving Medical Center, New York., Habiby R; Division of Endocrinology, Ann and Robert H. Lurie Children's Hospital, Chicago.; Feinberg School of Medicine, Northwestern University, Chicago., Ode KL; Division of Pediatric Endocrinology and Diabetes, Stead Family Department of Pediatrics, University of Iowa, Iowa City., Wabitsch M; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetes, University Hospital Ulm, Ulm, Germany.; German Center for Child and Adolescent Health (DZKJ), partner site, Ulm, Germany., Dattani M; Genetics and Genomic Medicine Programme, University College London Great Ormond Street Institute of Child Health, London., Abuzzahab MJ; Children's Minnesota, St. Paul., Abdullatif H; Department of Pediatric Endocrinology, University of Alabama, Birmingham., Morgan R; Lynn Health Science Institute, Oklahoma City., Stefater-Richards M; Division of Endocrinology, Boston Children's Hospital, Boston., Aroda VR; Brigham and Women's Hospital, Boston.; Harvard Medical School, Boston., Friedrich C; University Children's Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg, Oldenburg, Germany., Han JC; Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Diabetes, Obesity, and Metabolism Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York., Ono H; Chiba University Hospital, Chiba, Japan., Nagasaki K; Life Science Research Center, Nagano Children's Hospital, Nagano, Japan., Tanaka T; Nagoya City University Hospital, Nagoya, Japan., Isojima T; Department of Pediatrics, Toranomon Hospital, Tokyo., Arima H; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Scimia C; Rhythm Pharmaceuticals, Boston., Yuan G; Rhythm Pharmaceuticals, Boston., Müller HL; University Children's Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg, Oldenburg, Germany., Roth CL; Seattle Children's Research Institute, Norcliffe Foundation Center for Integrative Brain Research, Department of Pediatrics, University of Washington, Seattle.
Corporate Authors: TRANSCEND Trial Group
Source: The New England journal of medicine [N Engl J Med] 2026 Jul 09; Vol. 395 (2), pp. 138-150.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
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