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GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways.

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Title: GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways.
Authors: Lindquist P; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Dijkhof LRH; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Drzazga AK; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Lodz, Poland., Sabatier P; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark; Cardio-Thoracic Translational Medicine Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Stepniewski TM; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute & Pompeu Fabra University, Barcelona, Spain; InterAx Biotech AG, Villigen, Switzerland., Granlund L; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Lechner MY; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Zhong Y; Department of Physiology and Pharmacology and Center for Molecular Medicine, Karolinska Institutet and University Hospital, Stockholm, Sweden; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China., Gasbjerg LS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hartmann B; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lauschke VM; Department of Physiology and Pharmacology and Center for Molecular Medicine, Karolinska Institutet and University Hospital, Stockholm, Sweden; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China., Holst JJ; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Olsen JV; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Korsgren O; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden., Selent J; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute & Pompeu Fabra University, Barcelona, Spain., Wright SC; Department of Physiology and Pharmacology and Center for Molecular Medicine, Karolinska Institutet and University Hospital, Stockholm, Sweden., Hauser AS; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark; Center for Pharmaceutical Data Science Education, University of Copenhagen, Copenhagen, Denmark., Rosenkilde MM; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: rosenkilde@sund.ku.dk.
Source: Cell chemical biology [Cell Chem Biol] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lindquist+P%22">Lindquist P</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Dijkhof+LRH%22">Dijkhof LRH</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Drzazga+AK%22">Drzazga AK</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Lodz, Poland.<br /><searchLink fieldCode="AU" term="%22Sabatier+P%22">Sabatier P</searchLink>; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark; Cardio-Thoracic Translational Medicine Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Stepniewski+TM%22">Stepniewski TM</searchLink>; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute & Pompeu Fabra University, Barcelona, Spain; InterAx Biotech AG, Villigen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Granlund+L%22">Granlund L</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Lechner+MY%22">Lechner MY</searchLink>; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Zhong+Y%22">Zhong Y</searchLink>; Department of Physiology and Pharmacology and Center for Molecular Medicine, Karolinska Institutet and University Hospital, Stockholm, Sweden; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Gasbjerg+LS%22">Gasbjerg LS</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hartmann+B%22">Hartmann B</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Lauschke+VM%22">Lauschke VM</searchLink>; Department of Physiology and Pharmacology and Center for Molecular Medicine, Karolinska Institutet and University Hospital, Stockholm, Sweden; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Holst+JJ%22">Holst JJ</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Olsen+JV%22">Olsen JV</searchLink>; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Korsgren+O%22">Korsgren O</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Selent+J%22">Selent J</searchLink>; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute & Pompeu Fabra University, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wright+SC%22">Wright SC</searchLink>; Department of Physiology and Pharmacology and Center for Molecular Medicine, Karolinska Institutet and University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hauser+AS%22">Hauser AS</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark; Center for Pharmaceutical Data Science Education, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rosenkilde+MM%22">Rosenkilde MM</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: rosenkilde@sund.ku.dk.
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              Text: 2026 Jul 08
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