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GSK484 attenuates placental endothelial injury and improves gestation outcome in rats with preeclampsia by inhibiting PAD4-mediated neutrophil extracellular traps formation.

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Title: GSK484 attenuates placental endothelial injury and improves gestation outcome in rats with preeclampsia by inhibiting PAD4-mediated neutrophil extracellular traps formation.
Authors: Li YY; Department of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China; MOE Key Laboratory of Cellular Physiology, and the Department of Physiology, Shanxi Medical University, Taiyuan, China., Zhang ZY; The First Clinical Medical College of Shanxi Medical University, Taiyuan, China., Wang J; MOE Key Laboratory of Cellular Physiology, and the Department of Physiology, Shanxi Medical University, Taiyuan, China., Wang DP; MOE Key Laboratory of Cellular Physiology, and the Department of Physiology, Shanxi Medical University, Taiyuan, China., Zhao WF; Department of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China., Ma HJ; Department of Maternity, First Hospital of Shanxi Medical University, Taiyuan, China., Lin MM; College of Pharmacy, Chongqing Medical University, Chongqing, China; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Cao JM; MOE Key Laboratory of Cellular Physiology, and the Department of Physiology, Shanxi Medical University, Taiyuan, China. Electronic address: caojimin@sxmu.edu.cn., Han JB; Department of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China. Electronic address: hanjibin86@foxmail.com.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Jul 08; Vol. 1030, pp. 179123. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GSK484 attenuates placental endothelial injury and improves gestation outcome in rats with preeclampsia by inhibiting PAD4-mediated neutrophil extracellular traps formation.
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  Data: <searchLink fieldCode="AU" term="%22Li+YY%22">Li YY</searchLink>; Department of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China; MOE Key Laboratory of Cellular Physiology, and the Department of Physiology, Shanxi Medical University, Taiyuan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+ZY%22">Zhang ZY</searchLink>; The First Clinical Medical College of Shanxi Medical University, Taiyuan, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; MOE Key Laboratory of Cellular Physiology, and the Department of Physiology, Shanxi Medical University, Taiyuan, China.<br /><searchLink fieldCode="AU" term="%22Wang+DP%22">Wang DP</searchLink>; MOE Key Laboratory of Cellular Physiology, and the Department of Physiology, Shanxi Medical University, Taiyuan, China.<br /><searchLink fieldCode="AU" term="%22Zhao+WF%22">Zhao WF</searchLink>; Department of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.<br /><searchLink fieldCode="AU" term="%22Ma+HJ%22">Ma HJ</searchLink>; Department of Maternity, First Hospital of Shanxi Medical University, Taiyuan, China.<br /><searchLink fieldCode="AU" term="%22Lin+MM%22">Lin MM</searchLink>; College of Pharmacy, Chongqing Medical University, Chongqing, China; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Cao+JM%22">Cao JM</searchLink>; MOE Key Laboratory of Cellular Physiology, and the Department of Physiology, Shanxi Medical University, Taiyuan, China. Electronic address: caojimin@sxmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Han+JB%22">Han JB</searchLink>; Department of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China. Electronic address: hanjibin86@foxmail.com.
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  Data: <searchLink fieldCode="JN" term="%221254354%22">European journal of pharmacology</searchLink> [Eur J Pharmacol] 2026 Jul 08; Vol. 1030, pp. 179123. <i>Date of Electronic Publication: </i>2026 Jul 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>1254354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0712 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200142999%22">00142999 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejphar.2026.179123
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        Text: English
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      – TitleFull: GSK484 attenuates placental endothelial injury and improves gestation outcome in rats with preeclampsia by inhibiting PAD4-mediated neutrophil extracellular traps formation.
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              Text: 2026 Jul 08
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