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Spatial transcriptomic profiling of ovarian clear cell carcinoma reveals heterogeneity in OXPHOS and EMT gradients.

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Title: Spatial transcriptomic profiling of ovarian clear cell carcinoma reveals heterogeneity in OXPHOS and EMT gradients.
Authors: Truong Le T; Smart Medicine and Health Informatics Program, International College, National Taiwan University, Taipei, Taiwan, ROC.; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Wang DY; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Yan SR; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Chen YC; Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Chen KC; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore, Singapore., Chu PY; Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Chen DT; School of Medicine, College of Medicine, Keele University, Newcastle, UK., Chiu YC; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Sheu JY; Department of Urology, National Taiwan University Hospital, Taipei, Taiwan, ROC., Necesario SR; Department of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei, Taiwan, ROC., Huang CH; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ROC., Ye J; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Tai YT; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.; Department of Obstetrics & Gynecology, National Taiwan University Hospital, Taipei, Taiwan, ROC., Juan HF; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ROC.; Center for Advanced Computing and Imaging in Biomedicine, National Taiwan University, Taipei, Taiwan, ROC., Tsai FC; Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Lin WC; Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan, ROC., Chiang YC; Department of Obstetrics & Gynecology, National Taiwan University Hospital, Taipei, Taiwan, ROC. ycchiang@ntuh.gov.tw.; Department of Obstetrics & Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. ycchiang@ntuh.gov.tw.; Department of Obstetrics and Gynecology, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu City, Taiwan. ycchiang@ntuh.gov.tw., Wei LH; Department of Obstetrics & Gynecology, National Taiwan University Hospital, Taipei, Taiwan, ROC.; Department of Obstetrics & Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Huang RY; Smart Medicine and Health Informatics Program, International College, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; Department of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; Center for Advanced Computing and Imaging in Biomedicine, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; Department of Obstetrics & Gyneacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. rubyhuang@ntu.edu.tw.
Source: Nature communications [Nat Commun] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Spatial transcriptomic profiling of ovarian clear cell carcinoma reveals heterogeneity in OXPHOS and EMT gradients.
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  Data: <searchLink fieldCode="AU" term="%22Truong+Le+T%22">Truong Le T</searchLink>; Smart Medicine and Health Informatics Program, International College, National Taiwan University, Taipei, Taiwan, ROC.; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Wang+DY%22">Wang DY</searchLink>; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Yan+SR%22">Yan SR</searchLink>; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chen+KC%22">Chen KC</searchLink>; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Tan+TZ%22">Tan TZ</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chu+PY%22">Chu PY</searchLink>; Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chen+DT%22">Chen DT</searchLink>; School of Medicine, College of Medicine, Keele University, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Chiu+YC%22">Chiu YC</searchLink>; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Sheu+JY%22">Sheu JY</searchLink>; Department of Urology, National Taiwan University Hospital, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Necesario+SR%22">Necesario SR</searchLink>; Department of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Huang+CH%22">Huang CH</searchLink>; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Ye+J%22">Ye J</searchLink>; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Tai+YT%22">Tai YT</searchLink>; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.; Department of Obstetrics & Gynecology, National Taiwan University Hospital, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Juan+HF%22">Juan HF</searchLink>; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ROC.; Center for Advanced Computing and Imaging in Biomedicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Tsai+FC%22">Tsai FC</searchLink>; Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Lin+WC%22">Lin WC</searchLink>; Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chiang+YC%22">Chiang YC</searchLink>; Department of Obstetrics & Gynecology, National Taiwan University Hospital, Taipei, Taiwan, ROC. ycchiang@ntuh.gov.tw.; Department of Obstetrics & Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. ycchiang@ntuh.gov.tw.; Department of Obstetrics and Gynecology, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu City, Taiwan. ycchiang@ntuh.gov.tw.<br /><searchLink fieldCode="AU" term="%22Wei+LH%22">Wei LH</searchLink>; Department of Obstetrics & Gynecology, National Taiwan University Hospital, Taipei, Taiwan, ROC.; Department of Obstetrics & Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Huang+RY%22">Huang RY</searchLink>; Smart Medicine and Health Informatics Program, International College, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; Department of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; Center for Advanced Computing and Imaging in Biomedicine, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. rubyhuang@ntu.edu.tw.; Department of Obstetrics & Gyneacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. rubyhuang@ntu.edu.tw.
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