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Local autophagy impairment triggers brain-wide presynaptic remodeling and resilience.

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Title: Local autophagy impairment triggers brain-wide presynaptic remodeling and resilience.
Authors: Toppe D; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany., Huang S; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117, Berlin, Germany., Lützkendorf J; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany., Jiang PL; Department of Structural Biology, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125, Berlin, Germany., Suárez-Grimalt R; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany., Neumann A; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany., Zhao Z; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany., Lőrincz P; Institute of Genetics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary.; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary., Scheunemann L; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117, Berlin, Germany., Juhász G; Institute of Genetics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary.; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary., Liu F; Department of Structural Biology, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125, Berlin, Germany.; Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany., Maglione M; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117, Berlin, Germany.; Department of Biology, Chemistry, Pharmacy, Institute for Chemistry and Biochemistry, SupraFAB, 14195, Berlin, Germany., Sigrist SJ; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany. stephan.sigrist@fu-berlin.de.; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117, Berlin, Germany. stephan.sigrist@fu-berlin.de.
Source: The EMBO journal [EMBO J] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: Local autophagy impairment triggers brain-wide presynaptic remodeling and resilience.
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  Data: <searchLink fieldCode="AU" term="%22Toppe+D%22">Toppe D</searchLink>; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lützkendorf+J%22">Lützkendorf J</searchLink>; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Jiang+PL%22">Jiang PL</searchLink>; Department of Structural Biology, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Suárez-Grimalt+R%22">Suárez-Grimalt R</searchLink>; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Neumann+A%22">Neumann A</searchLink>; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lőrincz+P%22">Lőrincz P</searchLink>; Institute of Genetics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary.; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Scheunemann+L%22">Scheunemann L</searchLink>; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Juhász+G%22">Juhász G</searchLink>; Institute of Genetics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary.; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; Department of Structural Biology, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125, Berlin, Germany.; Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Maglione+M%22">Maglione M</searchLink>; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany.; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117, Berlin, Germany.; Department of Biology, Chemistry, Pharmacy, Institute for Chemistry and Biochemistry, SupraFAB, 14195, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sigrist+SJ%22">Sigrist SJ</searchLink>; Department of Biology, Chemistry, Pharmacy, Institute for Biology/Genetics, Freie Universität Berlin, 14195, Berlin, Germany. stephan.sigrist@fu-berlin.de.; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117, Berlin, Germany. stephan.sigrist@fu-berlin.de.
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