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Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice.

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Title: Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice.
Authors: Compagnion AC; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Ivanov A; Core Unit Bioinformatics, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany., Rana A; Denali Therapeutics, South San Francisco, CA, USA., Espinoza F; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Sandmann T; Denali Therapeutics, South San Francisco, CA, USA., Martineau FS; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Monsorno K; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Facchinetti R; Department of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy., Matera A; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Rougé L; Denali Therapeutics, South San Francisco, CA, USA., González Ibáñez F; Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Quebec City, Quebec, Canada.; School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada., Catale C; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, Université PSL, Team Brain Development and Plasticity, Paris, France.; Collège de France, Université PSL, Paris, France., Bizzotto M; IRCCS Humanitas Research Hospital, Rozzano, Italy., Garel S; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, Université PSL, Team Brain Development and Plasticity, Paris, France.; Collège de France, Université PSL, Paris, France., Matteoli M; IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Kashiwagi Y; Department of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Koyama R; Department of Translational Neurobiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan., Haass C; Biomedical Center (BMC), Department of Anatomy and Cell Biology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Tremblay ME; School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada., Beule D; Core Unit Bioinformatics, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany., Jelescu I; Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland., Zerbi V; Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Di Paolo G; Denali Therapeutics, South San Francisco, CA, USA., Paolicelli RC; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. rosachiara.paolicelli@unil.ch.
Source: Nature neuroscience [Nat Neurosci] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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  Data: Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice.
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  Data: <searchLink fieldCode="AU" term="%22Compagnion+AC%22">Compagnion AC</searchLink>; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ivanov+A%22">Ivanov A</searchLink>; Core Unit Bioinformatics, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Rana+A%22">Rana A</searchLink>; Denali Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Espinoza+F%22">Espinoza F</searchLink>; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sandmann+T%22">Sandmann T</searchLink>; Denali Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Martineau+FS%22">Martineau FS</searchLink>; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Monsorno+K%22">Monsorno K</searchLink>; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Facchinetti+R%22">Facchinetti R</searchLink>; Department of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Matera+A%22">Matera A</searchLink>; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rougé+L%22">Rougé L</searchLink>; Denali Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22González+Ibáñez+F%22">González Ibáñez F</searchLink>; Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Quebec City, Quebec, Canada.; School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Catale+C%22">Catale C</searchLink>; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, Université PSL, Team Brain Development and Plasticity, Paris, France.; Collège de France, Université PSL, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bizzotto+M%22">Bizzotto M</searchLink>; IRCCS Humanitas Research Hospital, Rozzano, Italy.<br /><searchLink fieldCode="AU" term="%22Garel+S%22">Garel S</searchLink>; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, Université PSL, Team Brain Development and Plasticity, Paris, France.; Collège de France, Université PSL, Paris, France.<br /><searchLink fieldCode="AU" term="%22Matteoli+M%22">Matteoli M</searchLink>; IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy.<br /><searchLink fieldCode="AU" term="%22Kashiwagi+Y%22">Kashiwagi Y</searchLink>; Department of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Koyama+R%22">Koyama R</searchLink>; Department of Translational Neurobiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Haass+C%22">Haass C</searchLink>; Biomedical Center (BMC), Department of Anatomy and Cell Biology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Tremblay+ME%22">Tremblay ME</searchLink>; School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Beule+D%22">Beule D</searchLink>; Core Unit Bioinformatics, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Jelescu+I%22">Jelescu I</searchLink>; Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zerbi+V%22">Zerbi V</searchLink>; Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Di+Paolo+G%22">Di Paolo G</searchLink>; Denali Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Paolicelli+RC%22">Paolicelli RC</searchLink>; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. rosachiara.paolicelli@unil.ch.
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