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Opportunities and challenges in the development of evolving EGFR inhibitors to overcome EGFR TKIs resistance.

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Title: Opportunities and challenges in the development of evolving EGFR inhibitors to overcome EGFR TKIs resistance.
Authors: Chen Y; Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200433, China., Liu QP; Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Yang SJ; School of Pharmacy, Jinan University, Guangzhou, 510632, China., Ding J; Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. jding@simm.ac.cn., Lu XY; School of Pharmacy, Jinan University, Guangzhou, 510632, China. luxy2016@jnu.edu.cn., Xie H; Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. hxie@simm.ac.cn.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. hxie@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200433, China.<br /><searchLink fieldCode="AU" term="%22Liu+QP%22">Liu QP</searchLink>; Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Yang+SJ%22">Yang SJ</searchLink>; School of Pharmacy, Jinan University, Guangzhou, 510632, China.<br /><searchLink fieldCode="AU" term="%22Ding+J%22">Ding J</searchLink>; Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. jding@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Lu+XY%22">Lu XY</searchLink>; School of Pharmacy, Jinan University, Guangzhou, 510632, China. luxy2016@jnu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xie+H%22">Xie H</searchLink>; Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. hxie@simm.ac.cn.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. hxie@simm.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Jul 08. <i>Date of Electronic Publication: </i>2026 Jul 08.
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        Value: 10.1038/s41401-026-01855-0
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              Text: 2026 Jul 08
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