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LacR and TrxB are key virulence factors involved in pneumococcal meningitis as identified by a genome-wide association study.

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Title: LacR and TrxB are key virulence factors involved in pneumococcal meningitis as identified by a genome-wide association study.
Authors: Koning R; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Jim KK; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location VU Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Kremer PHC; Department of Neurology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.; The Centre for Human Drug Research, Leiden, The Netherlands., Raymond Cheng HC; European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Hinxton, Cambridgeshire, UK.; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK., Jaspers V; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Perez M; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Ferwerda B; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Clinical Epidemiology and Biostatistics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Sewgoolam B; Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Ummels R; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location VU Universiteit Amsterdam, Amsterdam, The Netherlands., Boot M; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location VU Universiteit Amsterdam, Amsterdam, The Netherlands., Lees JA; European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Hinxton, Cambridgeshire, UK.; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK., Bentley SD; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK., Veening JW; Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Vandenbroucke-Grauls CMJE; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location VU Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Epidemiology, Infectious Diseases Surveillance and Epidemiology, Aarhus University, Aarhus, Denmark., Brouwer MC; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., van de Beek D; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands. d.vandebeek@amsterdamumc.nl.
Source: Communications biology [Commun Biol] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
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  Data: LacR and TrxB are key virulence factors involved in pneumococcal meningitis as identified by a genome-wide association study.
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  Data: <searchLink fieldCode="AU" term="%22Koning+R%22">Koning R</searchLink>; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jim+KK%22">Jim KK</searchLink>; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location VU Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kremer+PHC%22">Kremer PHC</searchLink>; Department of Neurology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.; The Centre for Human Drug Research, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Raymond+Cheng+HC%22">Raymond Cheng HC</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Hinxton, Cambridgeshire, UK.; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Jaspers+V%22">Jaspers V</searchLink>; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Perez+M%22">Perez M</searchLink>; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ferwerda+B%22">Ferwerda B</searchLink>; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Clinical Epidemiology and Biostatistics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sewgoolam+B%22">Sewgoolam B</searchLink>; Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ummels+R%22">Ummels R</searchLink>; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location VU Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Boot+M%22">Boot M</searchLink>; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location VU Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lees+JA%22">Lees JA</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Hinxton, Cambridgeshire, UK.; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bentley+SD%22">Bentley SD</searchLink>; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Veening+JW%22">Veening JW</searchLink>; Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vandenbroucke-Grauls+CMJE%22">Vandenbroucke-Grauls CMJE</searchLink>; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location VU Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Epidemiology, Infectious Diseases Surveillance and Epidemiology, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Brouwer+MC%22">Brouwer MC</searchLink>; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Beek+D%22">van de Beek D</searchLink>; Department of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands. d.vandebeek@amsterdamumc.nl.
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