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Olaparib in HR-deficient, metastatic triple-negative breast and platinum-sensitive relapsed ovarian cancers without germline mutations in BRCA1/2: phase 2 EMBRACE trial.

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Title: Olaparib in HR-deficient, metastatic triple-negative breast and platinum-sensitive relapsed ovarian cancers without germline mutations in BRCA1/2: phase 2 EMBRACE trial.
Authors: Sjoquist KM; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia. Katrin.sjoquist@sydney.edu.au.; Cancer Care Centre, St George Hospital, Kogarah, Australia. Katrin.sjoquist@sydney.edu.au.; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia. Katrin.sjoquist@sydney.edu.au., Dobrovic A; Department of Surgery, The University of Melbourne, Parkville, Australia., Robledo KP; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia., Nesic K; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Baron-Hay S; Royal North Shore Hospital, Sydney, Australia.; Breast Cancer Trials ANZ, Newcastle, Australia., Ananda S; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia.; Peter MacCallum Cancer Centre, Melbourne, Australia., McCarthy N; Breast Cancer Trials ANZ, Newcastle, Australia.; ICON Cancer Centre Wesley Auchenflower, Auchenflower, Australia., Goh J; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia.; Royal Brisbane & Women's Hospital, Herston, Australia., Steer C; Border Medical Oncology Research Unit, Albury Wodonga Regional Cancer Centre, Albury, Australia.; UNSW School of Clinical Medicine, Rural Clinical Campus, Albury, Australia., Murray N; Breast Cancer Trials ANZ, Newcastle, Australia.; Royal Adelaide Hospital, Adelaide, South Australia., Yip S; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia., Mileshkin LR; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia.; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia., Fink JL; XING Genomic Services, Brisbane, Australia., Chang G; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia., Bailey L; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia., Lee Y; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia., Zebic DS; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia.; Department of Medical Oncology, Wollongong Hospital, Wollongong, NSW, Australia., Kariyawasam UGIU; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Shield-Artin K; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Jarratt A; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Bedő J; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Papenfuss AT; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Kondrashova O; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Wakefield MJ; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Australia., Vandenberg CJ; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia., Stockler MR; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia., Scott CL; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia.; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Peter MacCallum Cancer Centre, Melbourne, Australia.; Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Australia., Waring PM; XING Genomic Services, Brisbane, Australia.; Department of Translational Pathology, AstraZeneca, Cambridge, UK.
Source: British journal of cancer [Br J Cancer] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: Olaparib in HR-deficient, metastatic triple-negative breast and platinum-sensitive relapsed ovarian cancers without germline mutations in BRCA1/2: phase 2 EMBRACE trial.
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  Data: <searchLink fieldCode="AU" term="%22Sjoquist+KM%22">Sjoquist KM</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia. Katrin.sjoquist@sydney.edu.au.; Cancer Care Centre, St George Hospital, Kogarah, Australia. Katrin.sjoquist@sydney.edu.au.; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia. Katrin.sjoquist@sydney.edu.au.<br /><searchLink fieldCode="AU" term="%22Dobrovic+A%22">Dobrovic A</searchLink>; Department of Surgery, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Robledo+KP%22">Robledo KP</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia.<br /><searchLink fieldCode="AU" term="%22Nesic+K%22">Nesic K</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Baron-Hay+S%22">Baron-Hay S</searchLink>; Royal North Shore Hospital, Sydney, Australia.; Breast Cancer Trials ANZ, Newcastle, Australia.<br /><searchLink fieldCode="AU" term="%22Ananda+S%22">Ananda S</searchLink>; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia.; Peter MacCallum Cancer Centre, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22McCarthy+N%22">McCarthy N</searchLink>; Breast Cancer Trials ANZ, Newcastle, Australia.; ICON Cancer Centre Wesley Auchenflower, Auchenflower, Australia.<br /><searchLink fieldCode="AU" term="%22Goh+J%22">Goh J</searchLink>; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia.; Royal Brisbane & Women's Hospital, Herston, Australia.<br /><searchLink fieldCode="AU" term="%22Steer+C%22">Steer C</searchLink>; Border Medical Oncology Research Unit, Albury Wodonga Regional Cancer Centre, Albury, Australia.; UNSW School of Clinical Medicine, Rural Clinical Campus, Albury, Australia.<br /><searchLink fieldCode="AU" term="%22Murray+N%22">Murray N</searchLink>; Breast Cancer Trials ANZ, Newcastle, Australia.; Royal Adelaide Hospital, Adelaide, South Australia.<br /><searchLink fieldCode="AU" term="%22Yip+S%22">Yip S</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia.<br /><searchLink fieldCode="AU" term="%22Mileshkin+LR%22">Mileshkin LR</searchLink>; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia.; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Fink+JL%22">Fink JL</searchLink>; XING Genomic Services, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Chang+G%22">Chang G</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia.<br /><searchLink fieldCode="AU" term="%22Bailey+L%22">Bailey L</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia.<br /><searchLink fieldCode="AU" term="%22Zebic+DS%22">Zebic DS</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia.; Department of Medical Oncology, Wollongong Hospital, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Kariyawasam+UGIU%22">Kariyawasam UGIU</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Shield-Artin+K%22">Shield-Artin K</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Jarratt+A%22">Jarratt A</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Bedő+J%22">Bedő J</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Papenfuss+AT%22">Papenfuss AT</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Kondrashova+O%22">Kondrashova O</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Wakefield+MJ%22">Wakefield MJ</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Vandenberg+CJ%22">Vandenberg CJ</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Stockler+MR%22">Stockler MR</searchLink>; NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia.<br /><searchLink fieldCode="AU" term="%22Scott+CL%22">Scott CL</searchLink>; Australia New Zealand Gynaecological Oncology Group, Sydney, Australia.; Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.; Peter MacCallum Cancer Centre, Melbourne, Australia.; Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Waring+PM%22">Waring PM</searchLink>; XING Genomic Services, Brisbane, Australia.; Department of Translational Pathology, AstraZeneca, Cambridge, UK.
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  Data: <searchLink fieldCode="JN" term="%220370635%22">British journal of cancer</searchLink> [Br J Cancer] 2026 Jul 08. <i>Date of Electronic Publication: </i>2026 Jul 08.
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