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Systemic immunosuppression limits NK cell therapy efficacy in pancreatic cancer.

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Title: Systemic immunosuppression limits NK cell therapy efficacy in pancreatic cancer.
Authors: He C; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA., Wang D; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Hu T; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Gonzalez D; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Thakur R; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Matysniak DP; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA., King RJ; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Kollala SS; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Markov SD; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Fujii Y; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA., Tej GNVC; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA., Zhao J; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA., Jin L; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA., Oberley-Deegan R; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Shukla SK; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; OU Health Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA., Zhang XA; Department of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA.; OU Health Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA., Friedman JE; Harold Hamm Diabetes Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73117, USA., Singh PK; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; OU Health Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA., Hollingsworth MA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA., di Magliano MP; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., Crawford HC; Department of Pharmacology and Toxicology, Michigan State University, Lansing, MI, USA.; Department of Surgery, Henry Ford Health System, Detroit, MI, USA., Mehla K; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA. kamiya-mehla@ouhsc.edu.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA. kamiya-mehla@ouhsc.edu.; Department of Microbiology and Immunology, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA. kamiya-mehla@ouhsc.edu.; Department of Pathology, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA. kamiya-mehla@ouhsc.edu.; OU Health Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA. kamiya-mehla@ouhsc.edu.
Source: Molecular cancer [Mol Cancer] 2026 Jul 08; Vol. 25 (1). Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Systemic immunosuppression limits NK cell therapy efficacy in pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22He+C%22">He C</searchLink>; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.<br /><searchLink fieldCode="AU" term="%22Hu+T%22">Hu T</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+D%22">Gonzalez D</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.<br /><searchLink fieldCode="AU" term="%22Thakur+R%22">Thakur R</searchLink>; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. 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Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22King+RJ%22">King RJ</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.<br /><searchLink fieldCode="AU" term="%22Kollala+SS%22">Kollala SS</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.<br /><searchLink fieldCode="AU" term="%22Markov+SD%22">Markov SD</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.<br /><searchLink fieldCode="AU" term="%22Fujii+Y%22">Fujii Y</searchLink>; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Tej+GNVC%22">Tej GNVC</searchLink>; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Jin+L%22">Jin L</searchLink>; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Oberley-Deegan+R%22">Oberley-Deegan R</searchLink>; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.<br /><searchLink fieldCode="AU" term="%22Shukla+SK%22">Shukla SK</searchLink>; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; OU Health Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+XA%22">Zhang XA</searchLink>; Department of Biochemistry and Physiology, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA.; OU Health Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Friedman+JE%22">Friedman JE</searchLink>; Harold Hamm Diabetes Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73117, USA.<br /><searchLink fieldCode="AU" term="%22Singh+PK%22">Singh PK</searchLink>; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; OU Health Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Hollingsworth+MA%22">Hollingsworth MA</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA.<br /><searchLink fieldCode="AU" term="%22di+Magliano+MP%22">di Magliano MP</searchLink>; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+HC%22">Crawford HC</searchLink>; Department of Pharmacology and Toxicology, Michigan State University, Lansing, MI, USA.; Department of Surgery, Henry Ford Health System, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Mehla+K%22">Mehla K</searchLink>; Department of Oncology Science, University of Oklahoma Health Campus, 940 Stanton L. Young Blvd., BMSB 332, Oklahoma City, OK, 73104, USA. kamiya-mehla@ouhsc.edu.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA. kamiya-mehla@ouhsc.edu.; Department of Microbiology and Immunology, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA. kamiya-mehla@ouhsc.edu.; Department of Pathology, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA. kamiya-mehla@ouhsc.edu.; OU Health Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA. kamiya-mehla@ouhsc.edu.
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