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Secondary Prophylaxis of Recurrent Clostridioides difficile Infections During Systemic Antibiotics with Vancomycin (SPORES-V): study protocol for a randomized controlled trial.

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Title: Secondary Prophylaxis of Recurrent Clostridioides difficile Infections During Systemic Antibiotics with Vancomycin (SPORES-V): study protocol for a randomized controlled trial.
Authors: Prosty C; Faculty of Medicine, McGill University, Montréal, Québec, Canada. connor.prosty@mail.mcgill.ca.; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada. connor.prosty@mail.mcgill.ca., Carignan A; Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, Québec, Canada., Chan AK; Division of Infectious Diseases, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada., Chen Y; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Daley P; Medicine and Lab Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Daneman N; Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada., Kandel C; Michael Garron Hospital, Toronto, ON, Canada., Longtin Y; Jewish General Hospital and Lady Davis Research Institute, Montréal, Québec, Canada., Perez-Patrigeon S; Division of Infectious Diseases, Department of Medicine, Queen's University, Kingston, ON, Canada., Wuerz T; Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada., Cheaveau J; Department of Hospitalist Medicine, East Kootenay Regional Hospital, Cranbrook, BC, Canada., Hota SS; Division of Infectious Diseases, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Infectious Diseases, Department of Medicine, University Health Network, Toronto, ON, Canada., Ogundipe O; Department of Internal Medicine, Cape Breton Regional Hospital, Sydney, NS, Canada.; Division of Infectious Diseases, Department of Medicine, Dalhousie University, Halifax, NS, Canada., Steiner TS; Department of Medicine and BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., Tsang JLY; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Niagara Health Knowledge Institute, Niagara Health, St. Catharines, ON, Canada., Archambault P; St. George Hospital, Lévis, Québec, Canada., Bergevin M; Cité de La Santé de Laval, Laval, Québec, Canada., Brophy JM; Department of Medicine and Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada., Girouard G; Department of Infectious Diseases, Georges-L.-Dumont University Hospital, Moncton, NB, Canada., Kong L; Jewish General Hospital and Lady Davis Research Institute, Montréal, Québec, Canada., Parkes L; Jewish General Hospital and Lady Davis Research Institute, Montréal, Québec, Canada., Reinblatt S; Patient Representative, Montréal, Québec, Canada., MacFadden D; The Ottawa Hospital Research Institute, Ottawa, ON, Canada., Lee TC; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada.; Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada.; Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada., McDonald EG; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada.; Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada.; Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada.
Source: Trials [Trials] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
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  Data: Secondary Prophylaxis of Recurrent Clostridioides difficile Infections During Systemic Antibiotics with Vancomycin (SPORES-V): study protocol for a randomized controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Prosty+C%22">Prosty C</searchLink>; Faculty of Medicine, McGill University, Montréal, Québec, Canada. connor.prosty@mail.mcgill.ca.; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada. connor.prosty@mail.mcgill.ca.<br /><searchLink fieldCode="AU" term="%22Carignan+A%22">Carignan A</searchLink>; Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Chan+AK%22">Chan AK</searchLink>; Division of Infectious Diseases, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Daley+P%22">Daley P</searchLink>; Medicine and Lab Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.<br /><searchLink fieldCode="AU" term="%22Daneman+N%22">Daneman N</searchLink>; Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kandel+C%22">Kandel C</searchLink>; Michael Garron Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Longtin+Y%22">Longtin Y</searchLink>; Jewish General Hospital and Lady Davis Research Institute, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Perez-Patrigeon+S%22">Perez-Patrigeon S</searchLink>; Division of Infectious Diseases, Department of Medicine, Queen's University, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wuerz+T%22">Wuerz T</searchLink>; Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Cheaveau+J%22">Cheaveau J</searchLink>; Department of Hospitalist Medicine, East Kootenay Regional Hospital, Cranbrook, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Hota+SS%22">Hota SS</searchLink>; Division of Infectious Diseases, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Infectious Diseases, Department of Medicine, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ogundipe+O%22">Ogundipe O</searchLink>; Department of Internal Medicine, Cape Breton Regional Hospital, Sydney, NS, Canada.; Division of Infectious Diseases, Department of Medicine, Dalhousie University, Halifax, NS, Canada.<br /><searchLink fieldCode="AU" term="%22Steiner+TS%22">Steiner TS</searchLink>; Department of Medicine and BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Tsang+JLY%22">Tsang JLY</searchLink>; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Niagara Health Knowledge Institute, Niagara Health, St. Catharines, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Archambault+P%22">Archambault P</searchLink>; St. George Hospital, Lévis, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Bergevin+M%22">Bergevin M</searchLink>; Cité de La Santé de Laval, Laval, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Brophy+JM%22">Brophy JM</searchLink>; Department of Medicine and Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Girouard+G%22">Girouard G</searchLink>; Department of Infectious Diseases, Georges-L.-Dumont University Hospital, Moncton, NB, Canada.<br /><searchLink fieldCode="AU" term="%22Kong+L%22">Kong L</searchLink>; Jewish General Hospital and Lady Davis Research Institute, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Parkes+L%22">Parkes L</searchLink>; Jewish General Hospital and Lady Davis Research Institute, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Reinblatt+S%22">Reinblatt S</searchLink>; Patient Representative, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22MacFadden+D%22">MacFadden D</searchLink>; The Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+TC%22">Lee TC</searchLink>; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada.; Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada.; Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22McDonald+EG%22">McDonald EG</searchLink>; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada.; Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada.; Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada.
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