Circulating tumor DNA in early breast cancer: Evidence, challenges, next steps.

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Title: Circulating tumor DNA in early breast cancer: Evidence, challenges, next steps.
Authors: Di Cosimo S; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Appierto V; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Reduzzi C; Liquid Biopsy Platform, Division of Hematology/Oncology, Weill Cornell Medicine, New York, New York, USA., De Cecco L; Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Valenza C; Division of New Drug and Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Gerratana L; Department of Medicine, University of Udine, Udine, Italy.; Department of Medical Oncology, CRO Aviano, National Cancer Institute IRCCS, Aviano, Italy., Agostinetto E; Service de Oncologie, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium., Llombart-Cussac A; Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain.; Translational Oncology Group, Department of Medicine, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera, Centro de Estudios Universitarios, Alfara del Patriarca, Spain.; Hospital Arnau de Vilanova, FISABIO, Valencia, Spain., Ignatiadis M; Service de Oncologie, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium., Cortes J; Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain.; International Breast Cancer Center-Pangaea Oncology, Quirón Group, Barcelona, Spain.; IOB Madrid, Institute of Oncology, Hospital Beata María Ana, Madrid, Spain.; Faculty of Biomedical and Health Sciences, Department of Medicine, Universidad Europea de Madrid, Madrid, Spain., Cristofanilli M; Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medicine, New York, New York, USA., Fusco N; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy., Curigliano G; Division of New Drug and Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Pruneri G; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Source: Cancer [Cancer] 2026 Jul 15; Vol. 132 (14), pp. e70521.
Publication Type: Journal Article; Review
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print Cited Medium: Internet ISSN: 1097-0142 (Electronic) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Di+Cosimo+S%22">Di Cosimo S</searchLink>; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Appierto+V%22">Appierto V</searchLink>; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Reduzzi+C%22">Reduzzi C</searchLink>; Liquid Biopsy Platform, Division of Hematology/Oncology, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22De+Cecco+L%22">De Cecco L</searchLink>; Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Valenza+C%22">Valenza C</searchLink>; Division of New Drug and Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gerratana+L%22">Gerratana L</searchLink>; Department of Medicine, University of Udine, Udine, Italy.; Department of Medical Oncology, CRO Aviano, National Cancer Institute IRCCS, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Agostinetto+E%22">Agostinetto E</searchLink>; Service de Oncologie, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Llombart-Cussac+A%22">Llombart-Cussac A</searchLink>; Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain.; Translational Oncology Group, Department of Medicine, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera, Centro de Estudios Universitarios, Alfara del Patriarca, Spain.; Hospital Arnau de Vilanova, FISABIO, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ignatiadis+M%22">Ignatiadis M</searchLink>; Service de Oncologie, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Cortes+J%22">Cortes J</searchLink>; Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain.; International Breast Cancer Center-Pangaea Oncology, Quirón Group, Barcelona, Spain.; IOB Madrid, Institute of Oncology, Hospital Beata María Ana, Madrid, Spain.; Faculty of Biomedical and Health Sciences, Department of Medicine, Universidad Europea de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cristofanilli+M%22">Cristofanilli M</searchLink>; Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Fusco+N%22">Fusco N</searchLink>; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Curigliano+G%22">Curigliano G</searchLink>; Division of New Drug and Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pruneri+G%22">Pruneri G</searchLink>; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
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