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Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort.

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Title: Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort.
Authors: Kostiniuk D; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Székely F; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary., Lyytikäinen LP; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Ciantar J; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Rajić S; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Mishra PP; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland., Lehtimäki T; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Paavo Nurmi Centre, Unit for Health and Physical Activity, University of Turku, Turku, Finland., Rovio S; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland., Mykkänen J; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Raitakari O; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Raitoharju E; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland., Marttila S; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland.; Gerontology Research Center, Tampere University, Tampere, Finland.
Source: Aging cell [Aging Cell] 2026 Jul; Vol. 25 (7), pp. e70626.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort.
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  Data: <searchLink fieldCode="AU" term="%22Kostiniuk+D%22">Kostiniuk D</searchLink>; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Székely+F%22">Székely F</searchLink>; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Lyytikäinen+LP%22">Lyytikäinen LP</searchLink>; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Ciantar+J%22">Ciantar J</searchLink>; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Rajić+S%22">Rajić S</searchLink>; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Mishra+PP%22">Mishra PP</searchLink>; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Lehtimäki+T%22">Lehtimäki T</searchLink>; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Pahkala+K%22">Pahkala K</searchLink>; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Paavo Nurmi Centre, Unit for Health and Physical Activity, University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Rovio+S%22">Rovio S</searchLink>; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Mykkänen+J%22">Mykkänen J</searchLink>; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Raitakari+O%22">Raitakari O</searchLink>; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Raitoharju+E%22">Raitoharju E</searchLink>; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Marttila+S%22">Marttila S</searchLink>; Molecular Epidemiology (MOLE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland.; Gerontology Research Center, Tampere University, Tampere, Finland.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101130839 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-9726 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214749718%22">14749718 </searchLink><i>NLM ISO Abbreviation: </i>Aging Cell <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul
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