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An Integrative RNA Spliceosomic Landscape of Pancreatic Neuroendocrine Tumors Identifies Clinically Relevant Molecular Subgroups.

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Title: An Integrative RNA Spliceosomic Landscape of Pancreatic Neuroendocrine Tumors Identifies Clinically Relevant Molecular Subgroups.
Authors: Blázquez-Encinas R; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain., García-Vioque V; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain., Mafficini A; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, University and Hospital Trust of Verona, Verona, Italy.; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy., Landoni L; Department of General and Pancreatic Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy., Ruiz-Palacios D; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain., Gutiérrez-Camacho L; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain., Moreno-Montilla MT; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain., Alcala N; Rare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organization (IARC/WHO), Lyon, 69008, France., Ventura S; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain.; Department of Computer Sciences, University of Córdoba, Córdoba, Spain., Eyras E; The John Curtin School of Medical Research, The Australian National University Canberra Australian Capital Territory, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University Canberra Australian Capital Territory Australia, Canberra, Australia., Paiella S; Department of General and Pancreatic Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy., Salvia R; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, University and Hospital Trust of Verona, Verona, Italy.; Department of General and Pancreatic Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy., Rovite V; Latvian Biomedical Research and Study Centre, Riga, Latvia., Foll M; Rare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organization (IARC/WHO), Lyon, 69008, France., Luchini C; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy., Fernandez-Cuesta L; Rare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organization (IARC/WHO), Lyon, 69008, France., Lawlor RT; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, University and Hospital Trust of Verona, Verona, Italy.; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy., Scarpa A; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy., Ibáñez-Costa A; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain. b12ibcoa@uco.es.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain. b12ibcoa@uco.es.; Reina Sofia University Hospital, Córdoba, Spain. b12ibcoa@uco.es.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain. b12ibcoa@uco.es., Pedraza-Arevalo S; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain. b92pears@uco.es.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain. b92pears@uco.es.; Reina Sofia University Hospital, Córdoba, Spain. b92pears@uco.es.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain. b92pears@uco.es., Castaño JP; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain. justo@uco.es.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain. justo@uco.es.; Reina Sofia University Hospital, Córdoba, Spain. justo@uco.es.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain. justo@uco.es.
Source: Endocrine pathology [Endocr Pathol] 2026 Jul 09; Vol. 37 (1). Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9009288 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0097 (Electronic) Linking ISSN: 10463976 NLM ISO Abbreviation: Endocr Pathol Subsets: MEDLINE
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  Data: An Integrative RNA Spliceosomic Landscape of Pancreatic Neuroendocrine Tumors Identifies Clinically Relevant Molecular Subgroups.
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  Data: <searchLink fieldCode="AU" term="%22Blázquez-Encinas+R%22">Blázquez-Encinas R</searchLink>; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22García-Vioque+V%22">García-Vioque V</searchLink>; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Mafficini+A%22">Mafficini A</searchLink>; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, University and Hospital Trust of Verona, Verona, Italy.; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Landoni+L%22">Landoni L</searchLink>; 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Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Alcala+N%22">Alcala N</searchLink>; Rare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organization (IARC/WHO), Lyon, 69008, France.<br /><searchLink fieldCode="AU" term="%22Ventura+S%22">Ventura S</searchLink>; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain.; Department of Computer Sciences, University of Córdoba, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Eyras+E%22">Eyras E</searchLink>; The John Curtin School of Medical Research, The Australian National University Canberra Australian Capital Territory, Canberra, Australia.; EMBL Australia Partner Laboratory Network at the Australian National University Canberra Australian Capital Territory Australia, Canberra, Australia.<br /><searchLink fieldCode="AU" term="%22Paiella+S%22">Paiella S</searchLink>; Department of General and Pancreatic Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Salvia+R%22">Salvia R</searchLink>; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, University and Hospital Trust of Verona, Verona, Italy.; Department of General and Pancreatic Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Rovite+V%22">Rovite V</searchLink>; Latvian Biomedical Research and Study Centre, Riga, Latvia.<br /><searchLink fieldCode="AU" term="%22Foll+M%22">Foll M</searchLink>; Rare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organization (IARC/WHO), Lyon, 69008, France.<br /><searchLink fieldCode="AU" term="%22Luchini+C%22">Luchini C</searchLink>; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Fernandez-Cuesta+L%22">Fernandez-Cuesta L</searchLink>; Rare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organization (IARC/WHO), Lyon, 69008, France.<br /><searchLink fieldCode="AU" term="%22Lawlor+RT%22">Lawlor RT</searchLink>; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, University and Hospital Trust of Verona, Verona, Italy.; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Scarpa+A%22">Scarpa A</searchLink>; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Ibáñez-Costa+A%22">Ibáñez-Costa A</searchLink>; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain. b12ibcoa@uco.es.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain. b12ibcoa@uco.es.; Reina Sofia University Hospital, Córdoba, Spain. b12ibcoa@uco.es.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain. b12ibcoa@uco.es.<br /><searchLink fieldCode="AU" term="%22Pedraza-Arevalo+S%22">Pedraza-Arevalo S</searchLink>; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain. b92pears@uco.es.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain. b92pears@uco.es.; Reina Sofia University Hospital, Córdoba, Spain. b92pears@uco.es.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain. b92pears@uco.es.<br /><searchLink fieldCode="AU" term="%22Castaño+JP%22">Castaño JP</searchLink>; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal s/n. 14004, Córdoba, Spain. justo@uco.es.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain. justo@uco.es.; Reina Sofia University Hospital, Córdoba, Spain. justo@uco.es.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain. justo@uco.es.
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