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Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.

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Title: Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.
Authors: Arnold WD; NextGen Precision Health, University of Missouri, Columbia, United States of America., Jeppesen Morgen J; NMD Pharma A/S, Aarhus, Denmark., Thomasen PB; NMD Pharma A/S, Aarhus, Denmark., Broch-Lips M; NMD Pharma A/S, Aarhus, Denmark., Clark LA; Ohio Musculoskeletal and Neurological Institute, Ohio University Heritage College of Osteopathic Medicine, Athens, United States of America., Groennebaek T; NMD Pharma A/S, Aarhus, Denmark., Skov M; NMD Pharma A/S, Aarhus, Denmark., Winther JB; NMD Pharma A/S, Aarhus, Denmark., Ramadan AF; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Vete, University of Edinburgh, Edinburgh, United Kingdom., Rust PA; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Vete, University of Edinburgh, Edinburgh, United Kingdom., Myers JH; Indian Institute of Technology, Kampur, India., Darvishi FB; NextGen Precision Health, University of Missouri, Columbia, United States of America., Dashtmian AR; NextGen Precision Health, University of Missouri, Columbia, United States of America., Fish LA; Department of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United States of America., Chugh D; Department of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United States of America., Bold J; NMD Pharma A/S, Aarhus, Denmark., Quiroz JA; NMD Pharma A/S, Aarhus, Denmark., Hutchison J; NMD Pharma A/S, Aarhus, Denmark., Nishimune H; NextGen Precision Health, University of Missouri, Columbia, United States of America., Jones RA; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Vete, University of Edinburgh, Edinburgh, United Kingdom., Wang X; Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, United States of America., Fallon JR; Department of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United States of America., Gillingwater TH; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Vete, University of Edinburgh, Edinburgh, United Kingdom., Rich MM; Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, United States of America., Pedersen TH; NMD Pharma A/S, Aarhus, Denmark., Clark BC; Ohio Musculoskeletal and Neurological Institute, Ohio University Heritage College of Osteopathic Medicine, Athens, United States of America.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Arnold+WD%22">Arnold WD</searchLink>; NextGen Precision Health, University of Missouri, Columbia, United States of America.<br /><searchLink fieldCode="AU" term="%22Jeppesen+Morgen+J%22">Jeppesen Morgen J</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Thomasen+PB%22">Thomasen PB</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Broch-Lips+M%22">Broch-Lips M</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Clark+LA%22">Clark LA</searchLink>; Ohio Musculoskeletal and Neurological Institute, Ohio University Heritage College of Osteopathic Medicine, Athens, United States of America.<br /><searchLink fieldCode="AU" term="%22Groennebaek+T%22">Groennebaek T</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Skov+M%22">Skov M</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Winther+JB%22">Winther JB</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Ramadan+AF%22">Ramadan AF</searchLink>; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Vete, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rust+PA%22">Rust PA</searchLink>; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Vete, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Myers+JH%22">Myers JH</searchLink>; Indian Institute of Technology, Kampur, India.<br /><searchLink fieldCode="AU" term="%22Darvishi+FB%22">Darvishi FB</searchLink>; NextGen Precision Health, University of Missouri, Columbia, United States of America.<br /><searchLink fieldCode="AU" term="%22Dashtmian+AR%22">Dashtmian AR</searchLink>; NextGen Precision Health, University of Missouri, Columbia, United States of America.<br /><searchLink fieldCode="AU" term="%22Fish+LA%22">Fish LA</searchLink>; Department of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United States of America.<br /><searchLink fieldCode="AU" term="%22Chugh+D%22">Chugh D</searchLink>; Department of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United States of America.<br /><searchLink fieldCode="AU" term="%22Bold+J%22">Bold J</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Quiroz+JA%22">Quiroz JA</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Hutchison+J%22">Hutchison J</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Nishimune+H%22">Nishimune H</searchLink>; NextGen Precision Health, University of Missouri, Columbia, United States of America.<br /><searchLink fieldCode="AU" term="%22Jones+RA%22">Jones RA</searchLink>; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Vete, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, United States of America.<br /><searchLink fieldCode="AU" term="%22Fallon+JR%22">Fallon JR</searchLink>; Department of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United States of America.<br /><searchLink fieldCode="AU" term="%22Gillingwater+TH%22">Gillingwater TH</searchLink>; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Vete, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rich+MM%22">Rich MM</searchLink>; Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, United States of America.<br /><searchLink fieldCode="AU" term="%22Pedersen+TH%22">Pedersen TH</searchLink>; NMD Pharma A/S, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Clark+BC%22">Clark BC</searchLink>; Ohio Musculoskeletal and Neurological Institute, Ohio University Heritage College of Osteopathic Medicine, Athens, United States of America.
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        Value: 10.1172/JCI190646
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        Text: English
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      – TitleFull: Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.
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              Text: 2026 Jul 09
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