2-Amino-3,4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X.
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| Title: | 2-Amino-3,4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X. |
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| Authors: | Dans MG; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Awalt JK; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Nguyen N; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Palandri J; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Ngo A; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Jarman KE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Jeon JH; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States., Yeo T; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States., Park H; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York New York 10032, United States., Uhlemann AC; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York New York 10032, United States., Mao EY; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Gancheva MR; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Wilson DW; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Mukherjee P; TCG Lifesciences, Kolkata, West Bengal 700091, India., Chakraborty A; TCG Lifesciences, Kolkata, West Bengal 700091, India., Kristan M; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Stewart L; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Sutherland CJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Baud D; MMV Medicines for Malaria Venture, Geneva 1215, Switzerland., Brand S; MMV Medicines for Malaria Venture, Geneva 1215, Switzerland., Fidock DA; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York New York 10032, United States., Jackson PF; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC, La Jolla, California 92121, United States., Cowman AF; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia. |
| Source: | ACS infectious diseases [ACS Infect Dis] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42424440 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: 2-Amino-3,4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Dans+MG%22">Dans MG</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Awalt+JK%22">Awalt JK</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen+N%22">Nguyen N</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Palandri+J%22">Palandri J</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Ngo+A%22">Ngo A</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Jarman+KE%22">Jarman KE</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Jeon+JH%22">Jeon JH</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Yeo+T%22">Yeo T</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Park+H%22">Park H</searchLink>; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Uhlemann+AC%22">Uhlemann AC</searchLink>; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Mao+EY%22">Mao EY</searchLink>; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Gancheva+MR%22">Gancheva MR</searchLink>; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Wilson+DW%22">Wilson DW</searchLink>; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Mukherjee+P%22">Mukherjee P</searchLink>; TCG Lifesciences, Kolkata, West Bengal 700091, India.<br /><searchLink fieldCode="AU" term="%22Chakraborty+A%22">Chakraborty A</searchLink>; TCG Lifesciences, Kolkata, West Bengal 700091, India.<br /><searchLink fieldCode="AU" term="%22Kristan+M%22">Kristan M</searchLink>; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.<br /><searchLink fieldCode="AU" term="%22Stewart+L%22">Stewart L</searchLink>; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.<br /><searchLink fieldCode="AU" term="%22Sutherland+CJ%22">Sutherland CJ</searchLink>; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.<br /><searchLink fieldCode="AU" term="%22Baud+D%22">Baud D</searchLink>; MMV Medicines for Malaria Venture, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brand+S%22">Brand S</searchLink>; MMV Medicines for Malaria Venture, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fidock+DA%22">Fidock DA</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Jackson+PF%22">Jackson PF</searchLink>; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC, La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Cowman+AF%22">Cowman AF</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Sleebs+BE%22">Sleebs BE</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101654580%22">ACS infectious diseases</searchLink> [ACS Infect Dis] 2026 Jul 09. <i>Date of Electronic Publication: </i>2026 Jul 09. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ACS+Publications%22">ACS Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101654580 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2373-8227 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223738227%22">23738227 </searchLink><i>NLM ISO Abbreviation: </i>ACS Infect Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42424440 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acsinfecdis.6c00258 Languages: – Code: eng Text: English Titles: – TitleFull: 2-Amino-3,4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dans MG – PersonEntity: Name: NameFull: Awalt JK – PersonEntity: Name: NameFull: Nguyen N – PersonEntity: Name: NameFull: Palandri J – PersonEntity: Name: NameFull: Ngo A – PersonEntity: Name: NameFull: Jarman KE – PersonEntity: Name: NameFull: Jeon JH – PersonEntity: Name: NameFull: Yeo T – PersonEntity: Name: NameFull: Park H – PersonEntity: Name: NameFull: Uhlemann AC – PersonEntity: Name: NameFull: Mao EY – PersonEntity: Name: NameFull: Gancheva MR – PersonEntity: Name: NameFull: Wilson DW – PersonEntity: Name: NameFull: Mukherjee P – PersonEntity: Name: NameFull: Chakraborty A – PersonEntity: Name: NameFull: Kristan M – PersonEntity: Name: NameFull: Stewart L – PersonEntity: Name: NameFull: Sutherland CJ – PersonEntity: Name: NameFull: Baud D – PersonEntity: Name: NameFull: Brand S – PersonEntity: Name: NameFull: Fidock DA – PersonEntity: Name: NameFull: Jackson PF – PersonEntity: Name: NameFull: Cowman AF – PersonEntity: Name: NameFull: Sleebs BE IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 07 Text: 2026 Jul 09 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2373-8227 Titles: – TitleFull: ACS infectious diseases Type: main |
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