Aspirin for cancer prevention in individuals with Lynch syndrome: first results from the CaPP3 multicentre, randomised, double-blind, non-inferiority trial.
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| Title: | Aspirin for cancer prevention in individuals with Lynch syndrome: first results from the CaPP3 multicentre, randomised, double-blind, non-inferiority trial. |
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| Authors: | Burn J; Newcastle University Translational & Clinical Research Institute, Centre for Life, Newcastle upon Tyne, UK; The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. Electronic address: john.burn@newcastle.ac.uk., Borthwick GM; Newcastle University Translational & Clinical Research Institute, Centre for Life, Newcastle upon Tyne, UK., Elliott F; Institute of Medical Research, University of Leeds, Leeds, UK., Macrae F; Royal Melbourne Hospital, Parkville, VIC, Australia., Ong KR; Birmingham Women's and Children's NHS Trust, Department of Clinical Genetics, Birmingham, UK., Kraus AC; Leeds Clinical Genomics Service, Leeds Teaching Hospitals NHS Trust, Chapel Allerton Hospital, Leeds, UK., Arber N; Tel Aviv Medical Center, Tel Aviv, Israel., Mecklin JP; Department of Education and Research, The Wellbeing Services County of Central Finland, Jyväskylä, Finland and Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Alonso A; Genomic Medicine Unit, Navarrabiomed-Universidad Pública de Navarra (UPNA) Hospital Universitario de Navarra (HUN), IdiSNA, Pamplona, Navarra, Spain., Woodward ER; Division of Evolution Infection and Genomic Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester, UK., Evans DG; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Murray A; Wales Genomics Health Centre, Cardiff, UK., Snape K; St George's University Hospitals NHS Foundation Trust, London, UK., Cleaver RE; Peninsula Clinical Genetics, Royal Devon and Exeter (Heavitree), Exeter, UK., Shaw A; Clinical Genetics, Guy's Hospital, London, UK., Thomas HJW; St Marks Hospital, Harrow, Middlesex, UK; Faculty of Medicine, Imperial College London, London, UK., Kumar AV; North East Thames Regional Genetics Service, Great Ormond Street Hospital, London, UK., Halliday D; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Side LE; University Hospital Southampton NHS Trust, Southampton General Hospital, Southampton, Hampshire, UK., Harrison RE; Nottingham University Hospitals, City Campus, Nottingham, UK., Davidson R; West of Scotland Centre for Genomic Medicine, Queen Elizabeth University Hospital, Glasgow, UK., Armstrong R; Department of Clinical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Cook J; Sheffield Children's Hospital, Sheffield, UK., Hart R; Liverpool Women's Hospital, Liverpool, UK., Morrison PJ; Patrick G Johnston Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, UK., Barwell JG; Clinical Genetics, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK., Donaldson A; Clinical Genetics Service, St Michaels Hospital, Bristol, UK., Kemp Z; The Royal Marsden NHS Trust, London, UK., Murray J; South East Scotland Clinical Genetics Service, Western General Hospital, Edinburgh, UK., Miedzybrodzka Z; Clinical Genetics Centre, Ashgrove House Aberdeen Royal Infirmary, Aberdeen, UK., Pottinger C; All Wales Medical Genomics Service, Wrexham Maelor Hospital, Wrexham, UK., Berg J; University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Gallon R; Newcastle University Translational & Clinical Research Institute, Centre for Life, Newcastle upon Tyne, UK., Bishop DT; Institute of Medical Research, University of Leeds, Leeds, UK. Electronic address: d.t.bishop@leeds.ac.uk. |
| Corporate Authors: | CaPP3 co-investigators |
| Source: | The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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