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Targeting microglial TLR3-NF-κB/MAPK and JAK/STAT Axis: PEITC as a suppressor of poly (I:C)-induced neuroinflammation.

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Title: Targeting microglial TLR3-NF-κB/MAPK and JAK/STAT Axis: PEITC as a suppressor of poly (I:C)-induced neuroinflammation.
Authors: Lan YC; Department of Chinese Medicine, Chang Bing Show Chwan Memorial Hospital, Lukang Township, Changhua 50544, Taiwan., Xiao YR; School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan., Hsieh YW; Department of Pharmacy, China Medical University Hospital, Taichung City 40447, Taiwan., Cheng YD; Department of Pharmacy, China Medical University Hospital, Taichung City 40447, Taiwan., Peng SF; Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan., Chueh FS; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, 41354, Taiwan., Lee HT; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan; Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407219, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan., Hsieh YS; Department of Electrical Engineering, National Chung Cheng University, Chiayi 621301, Taiwan., Jiang WC; Department of Electrical Engineering, National Chung Cheng University, Chiayi 621301, Taiwan., Hsieh WT; Department of Pharmacy, China Medical University Hospital, Taichung City 40447, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung City 404333, Taiwan; Department of Pharmacology, School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan. Electronic address: wthsieh@mail.cmu.edu.tw., Chou YC; Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407219, Taiwan; Department of Applied Chemistry, National Chi Nan University, Nantou 54561, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 114, Taiwan. Electronic address: chouycns@vghtc.gov.tw.
Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2026 Sep; Vol. 514, pp. 117942. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting microglial TLR3-NF-κB/MAPK and JAK/STAT Axis: PEITC as a suppressor of poly (I:C)-induced neuroinflammation.
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  Data: <searchLink fieldCode="AU" term="%22Lan+YC%22">Lan YC</searchLink>; Department of Chinese Medicine, Chang Bing Show Chwan Memorial Hospital, Lukang Township, Changhua 50544, Taiwan.<br /><searchLink fieldCode="AU" term="%22Xiao+YR%22">Xiao YR</searchLink>; School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+YW%22">Hsieh YW</searchLink>; Department of Pharmacy, China Medical University Hospital, Taichung City 40447, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+YD%22">Cheng YD</searchLink>; Department of Pharmacy, China Medical University Hospital, Taichung City 40447, Taiwan.<br /><searchLink fieldCode="AU" term="%22Peng+SF%22">Peng SF</searchLink>; Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chueh+FS%22">Chueh FS</searchLink>; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, 41354, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+HT%22">Lee HT</searchLink>; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan; Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407219, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+YS%22">Hsieh YS</searchLink>; Department of Electrical Engineering, National Chung Cheng University, Chiayi 621301, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jiang+WC%22">Jiang WC</searchLink>; Department of Electrical Engineering, National Chung Cheng University, Chiayi 621301, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+WT%22">Hsieh WT</searchLink>; Department of Pharmacy, China Medical University Hospital, Taichung City 40447, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung City 404333, Taiwan; Department of Pharmacology, School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan. Electronic address: wthsieh@mail.cmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chou+YC%22">Chou YC</searchLink>; Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407219, Taiwan; Department of Applied Chemistry, National Chi Nan University, Nantou 54561, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 114, Taiwan. Electronic address: chouycns@vghtc.gov.tw.
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  Data: <searchLink fieldCode="JN" term="%220416575%22">Toxicology and applied pharmacology</searchLink> [Toxicol Appl Pharmacol] 2026 Sep; Vol. 514, pp. 117942. <i>Date of Electronic Publication: </i>2026 Jul 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0416575 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-0333 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220041008X%22">0041008X </searchLink><i>NLM ISO Abbreviation: </i>Toxicol Appl Pharmacol <i>Subsets: </i>MEDLINE
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              M: 09
              Text: 2026 Sep
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