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Does lifestyle intervention lower clinically significant cognitive impairment risk?

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Title: Does lifestyle intervention lower clinically significant cognitive impairment risk?
Authors: Espeland MA; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Neiberg RH; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Rapp SR; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.; Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winson-Salem, North Carolina, USA., Luchsinger JA; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, New York, USA., Sachs BC; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.; Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Mielke MM; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Carmichael O; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Yasar S; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Chen H; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Spira AP; Department of Mental Health, Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine, Johns Hopkins Center on Aging and Health, Baltimore, Maryland, USA., Momoh CT; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Baker LD; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Houston DK; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Wagenknecht LM; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Semelka C; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Beckner T; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Hayden KM; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jul; Vol. 22 (7), pp. e71668.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Espeland+MA%22">Espeland MA</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Neiberg+RH%22">Neiberg RH</searchLink>; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Rapp+SR%22">Rapp SR</searchLink>; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.; Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winson-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Luchsinger+JA%22">Luchsinger JA</searchLink>; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Sachs+BC%22">Sachs BC</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.; Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Mielke+MM%22">Mielke MM</searchLink>; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Carmichael+O%22">Carmichael O</searchLink>; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Yasar+S%22">Yasar S</searchLink>; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Spira+AP%22">Spira AP</searchLink>; Department of Mental Health, Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine, Johns Hopkins Center on Aging and Health, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Momoh+CT%22">Momoh CT</searchLink>; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Baker+LD%22">Baker LD</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Houston+DK%22">Houston DK</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Wagenknecht+LM%22">Wagenknecht LM</searchLink>; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Semelka+C%22">Semelka C</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Beckner+T%22">Beckner T</searchLink>; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Hayden+KM%22">Hayden KM</searchLink>; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Jul; Vol. 22 (7), pp. e71668.
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              Text: 2026 Jul
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